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antispasmodic effect

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By Targets:	AMPK (2) Apoptosis (1) Bcl-2 Family (1) Biochemical Assay Reagents (2) Cytochrome P450 (1) Endogenous Metabolite (2) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) mAChR (1) P-glycoprotein (1) Reference Standards (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (5)
Oligonucleotides:	Phospholipids (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113123

LysoPC(14:0/0:0) 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine	Endogenous Metabolite	Neurological Disease Metabolic Disease
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

HY-N4113

Glycycoumarin	Keap1-Nrf2 AMPK	Cancer
Glycycoumarin is a potent *antispasmodic* agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .

HY-N8117

Bisabolol oxide A	Biochemical Assay Reagents	Inflammation/Immunology
Bisabolol oxide A is a bisabolane-type sesquiterpenoid found in the flowers of Matricaria chamomilla. Bisabolol oxide A contributes to the antispasmodic effect of chamomile preparations .

HY-N2050

1,3,5,8-Tetrahydroxyxanthone 1 Publications Verification Desmethylbellidifolin	Others	Neurological Disease Inflammation/Immunology
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Swertia chirata. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity .

HY-113123S1

LysoPC(14:0/0:0)-d7 14:0 Lyso PC-d₇; 1-myristoyl-sn-glycero-3-phosphatidylcholine-d₇	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease Metabolic Disease
LysoPC(14:0/0:0)-d₇ (14:0 Lyso PC-d₇) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

HY-111025

Ectylurea	Others	Neurological Disease
Ectylurea, a N-acylurea, can be used in studies of tension and anxiety symptoms, has no effect on the autonomic nervous system, and has no convulsive, analgesic or antispasmodic activity in animals .

HY-136634

BTM-1042	mAChR	Others
BTM-1042 is a newly synthesized compound with antispasmodic effects. It can inhibit the twitch reaction of the guinea pig ileum under electrical stimulation and is not affected by naloxone. It has similar effects to atropine and can block muscarinic receptors, but has less effect on other types of receptors. BTM-1042 also has an inhibitory effect on the ileal reaction caused by nicotine and 5-hydroxytryptamine. BTM-1042 showed a dose-dependent inhibitory effect on the spontaneous movement of the rabbit stomach. In general, BTM-1042 is a agent with a strong antispasmodic effect.

HY-N4113R

Glycycoumarin (Standard)	Reference Standards Keap1-Nrf2 AMPK	Cancer
Glycycoumarin (Standard) is the analytical standard of Glycycoumarin. This product is intended for research and analytical applications. Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .

HY-N8117R

Bisabolol oxide A (Standard)	Reference Standards Biochemical Assay Reagents	Inflammation/Immunology
Bisabolol oxide A (Standard) is the analytical standard of Bisabolol oxide A (HY-N8117). This product is intended for research and analytical applications. Bisabolol oxide A is a bisabolane-type sesquiterpenoid found in the flowers of Matricaria chamomilla. Bisabolol oxide A contributes to the antispasmodic effect of chamomile preparations .

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Cytochrome P450 P-glycoprotein	Neurological Disease Inflammation/Immunology Cancer
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-N15424

Himachalol	Apoptosis Bcl-2 Family
Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level). Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD₅₀ of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113123

LysoPC(14:0/0:0) 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine	Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

HY-N4113

Glycycoumarin	Classification of Application Fields Leguminosae Coumarins Phenols Polyphenols Phenylpropanoids Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Keap1-Nrf2 AMPK
Glycycoumarin is a potent *antispasmodic* agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .

HY-N8117

Bisabolol oxide A	Structural Classification Natural Products Classification of Application Fields Distemonanthus benthamianus Baill. Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	Biochemical Assay Reagents
Bisabolol oxide A is a bisabolane-type sesquiterpenoid found in the flowers of Matricaria chamomilla. Bisabolol oxide A contributes to the antispasmodic effect of chamomile preparations .

HY-N2050

1,3,5,8-Tetrahydroxyxanthone 1 Publications Verification Desmethylbellidifolin	other families Xanthones Neurological Disease Classification of Application Fields Gentianaceae Phenols Polyphenols Swertia chirata Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Swertia chirata. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity .

HY-N4113R

Glycycoumarin (Standard)	Structural Classification Leguminosae Coumarins Phenols Polyphenols Phenylpropanoids Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards Keap1-Nrf2 AMPK
Glycycoumarin (Standard) is the analytical standard of Glycycoumarin. This product is intended for research and analytical applications. Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .

HY-N8117R

Bisabolol oxide A (Standard)	Structural Classification Natural Products Distemonanthus benthamianus Baill. Plants Compositae Source Classification	Reference Standards Biochemical Assay Reagents
Bisabolol oxide A (Standard) is the analytical standard of Bisabolol oxide A (HY-N8117). This product is intended for research and analytical applications. Bisabolol oxide A is a bisabolane-type sesquiterpenoid found in the flowers of Matricaria chamomilla. Bisabolol oxide A contributes to the antispasmodic effect of chamomile preparations .

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Alkaloids Piperidine Alkaloids Piperaceae Plants Piper nigrum Linn. Source Classification	Cytochrome P450 P-glycoprotein
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-N15424

Himachalol	Cedrus deodara (Roxburgh) G. Don Pinaceae Terpenoids Sesquiterpenes Plants Source Classification	Apoptosis Bcl-2 Family
Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level). Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD₅₀ of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) .

Cat. No.	Product Name	Chemical Structure

HY-113123S1

LysoPC(14:0/0:0)-d7
LysoPC(14:0/0:0)-d₇ (14:0 Lyso PC-d₇) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

Cat. No.	Product Name		Classification

HY-113123

LysoPC(14:0/0:0) 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine		Phospholipids
LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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antispasmodic effect

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products