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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
base hydrolysis
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "base hydrolysis" in MCE Product Catalog:
8
8 Cited Publications
Cat. No.: HY-B0689
CAS No.: 150378-17-9
Synonyms: MK-639 free base; L-735524 free base
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Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL pro inhibitor .
Cat. No.: HY-P2661
CAS No.: 78832-65-2
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Hemicellulase is a hemicellulose-targeting hydrolase that breaks down the binding of glucose and polymers to water molecules present in plant fibers. Hemicellulase specifically degrades hemicellulose (such as xylan and mannan) in plant cell walls by hydrolyzing β-1,4-xylosidic bonds and ester bonds (such as acetyl and ferulic acid ester bonds). Hemicellulase relies on the synergistic action of the glycoside hydrolase (GH) and carbohydrate esterase (CE) families to achieve efficient hydrolysis through acid-base catalysis (such as Glu/Asp residues) and substrate binding pockets. Hemicellulase can be used in the food industry (such as improving bread texture)， biofuel production (lignocellulose pretreatment) and paper industry (biobleaching) .
Cat. No.: HY-N6675
CAS No.: 94238-00-3
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Natural Products Neurological Disease Lridaceae Plants Crocus sativus L. Disease Research Fields Cancer
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Cat. No.: HY-150251
CAS No.: 2497583-03-4
Synonyms: STAT3 degrader-2
SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506) .
Cat. No.: HY-W391506
CAS No.: 9011-14-7
Synonyms: Poly(methyl methacrylate), beads; PMMA
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Poly (methyl methacrylate) (Poly(methyl methacrylate), beads; PMMA) is an amorphous glassy acrylic thermoplastic polymer belonging to the acrylate family, synthesized from methyl methacrylate monomers. Poly (methyl methacrylate) drives biochemical processes including free volume expansion induced by inelastic deformation, yield stress and strain softening regulated by physical aging, acid hydrolysis to polymethacrylic acid, multi-stage combustion, oxygen-dependent thermal decomposition, primary amine-mediated polypentanimide formation, and grafting/crosslinking-based copolymer and composite formation. Poly (methyl methacrylate) exhibits histocompatibility, low toxicity, low inflammatory potential, and fracture resistance; it can form functional blends and composites for biomedical and dental applications; it also allows performance-enhancing chemical and mechanical modifications. Poly (methyl methacrylate) is applicable to studies related to cranial repair .
Cat. No.: HY-133724
CAS No.: 448184-48-3
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Vardenafil N-oxide is a N-Oxide impurity of Vardenafil (HY-B0442) .
Cat. No.: HY-E70217
CAS No.: 59088-21-0
Synonyms: Heat-sensitive UDG
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Uracil DNA Glycosylase (UDG/UNG), heat-sensitive (Heat-sensitive UDG) can catalyze the hydrolysis of the N-glycosidic bond between the uracil base and the sugar phosphate backbone in the DNA chain containing uracil, releasing free uracil. Uracil DNA Glycosylase (UDG/UNG), heat-sensitive eliminates the carryover contamination dUTP-incorporated amplification products .
Cat. No.: HY-167885
CAS No.: 1450615-41-4
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Cat. No.: HY-133724R
CAS No.: 448184-48-3
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Vardenafil N-oxide (Standard) is the analytical standard of Vardenafil N-oxide. This product is intended for research and analytical applications. Vardenafil N-oxide is a N-Oxide impurity of Vardenafil (HY-B0442) .
Cat. No.: HY-164949
CAS No.: 2762182-61-4
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Ribociclib acetate is a degradation product of Ribociclib (HY-15777) under acid-base hydrolysis conditions. Ribociclib acetate has been predicted to be carcinogenic .
Cat. No.: HY-101630A
CAS No.: 120444-72-6
Synonyms: EGIS-3886 fumarate
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Deramciclane fumarate is an antagonist of 5-HT Receptor. Deramciclane fumarate is an inverse agonist of 5-HT2C Receptor with an IC50 of 168 nM. Deramciclane fumarate also decreases basal phosphoinositide hydrolysis .
Cat. No.: HY-164685
CAS No.: 324572-92-1
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T-0156 free base is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 free base specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 free base inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 free base enhances the nitric oxide (NO)/cGMP pathway .
Cat. No.: HY-B0689S1
Synonyms: MK-639 free base-13C4,15N; L-735524 free base-13C4,15N
Cat. No.: HY-D1687
Cat. No.: HY-P5415
CAS No.: 127134-13-8
Cat. No.: HY-103566A
CAS No.: 338738-57-1
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LY456236 free base is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 free base can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 free base blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 free base can be used in epilepsy research .
Synonyms: (E/Z)-Allyl-glucosinolate free base; (E/Z)-2-Propenyl-glucosinolate free base
Cat. No.: HY-K0615
MCE ATPase Staining Kit for Muscle Fibers (Calcium Activation Method) is based on the hydrolysis of ATP by ATPase, which generates ADP and inorganic phosphate. Phosphate combines with calcium ions to form colorless calcium phosphate precipitates. Calcium phosphate is then treated with cobalt chloride to form cobalt phosphate, which, after treatment with sulfide solution, results in the formation of brown-black cobalt sulfide precipitates at the enzyme activity sites.
Cat. No.: HY-184777
CAS No.: 94367-34-7
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Met-AMC is a fluorescent substrate used to detect the activity of methionine aminopeptidase (MetAP). Hydrolysis of the substrate releases the fluorophore AMC, with detection performed at an excitation wavelength of 360 nm and an emission wavelength of 460 nm. Met-AMC can distinguish the effects of different metal cofactors on the substrate preference of MetAP1: Zn (II)-MetAP1 barely hydrolyzes Met-AMC, while Co (II)-, Mn (II)-, and Ni (II)-MetAP1 can stably cleave this substrate. Met-AMC can be used to establish an intracellular MetAP activity cell-based assay system, which quantifies the intracellular MetAP inhibition level by monitoring the fluorescence signal from substrate hydrolysis in living cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
