120444-72-6
120444-72-6
Chemical Structure
Deramciclane fumarate
Synonym(s): EGIS-3886 fumarate
- CAS No.: 120444-72-6
- Formula:C24H35NO5
- Molecular Weight:417.54
IUPAC Name: N,N-dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethan-1-amine fumarate
InChIKey: RFQWRWCCNQNACG-HJYQBBATSA-N
SMILES: CC1(C)[C@]2(C)[C@@](OCCN(C)C)(C3=CC=CC=C3)C[C@@]1([H])CC2.O=C(O)/C=C/C(O)=O
Biological Activity: Deramciclane fumarate is an antagonist of 5-HT Receptor. Deramciclane fumarate is an inverse agonist of 5-HT2C Receptor with an IC50 of 168 nM. Deramciclane fumarate also decreases basal phosphoinositide hydrolysis[1][2].
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Deramciclane fumarate | Deramciclane fumarate is an antagonist of 5-HT Receptor. Deramciclane fumarate is an inverse agonist of 5-HT2C Receptor with an IC50 of 168 nM. Deramciclane fumarate also decreases basal phosphoinositide hydrolysis. | |||||||||||||||||||||
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References
- [1]. Pälvimäki EP, et al. eramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation. Psychopharmacology (Berl). 1998 Mar;136(2):99-104. [Content Brief]
- [2]. Kääriäinen TM, et al. Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats. Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):50-8. [Content Brief]
