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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
caspase-4
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "caspase-4" in MCE Product Catalog:
177
177 Publications Verification
Synonyms: VX-765
Target:
Research Areas:
Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
12
12 Cited Publications
Target:
Research Areas:
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3 .
6
5
5 Cited Publications
Target:
Research Areas:
VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively .
4
Research Areas:
Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM . Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca 2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 .
1
1 Cited Publications
Cat. No.: HY-P3115
CAS No.: 1092077-23-0
Research Areas:
Cat. No.: HY-B1193R
CAS No.: 50679-08-8
Synonyms: (±)-Terfenadine (Standard); MDL-991 (Standard)
Target:
Reference Standards Potassium Channel Histamine Receptor Na+/Ca2+ Exchanger Caspase Apoptosis
Research Areas:
Terfenadine (Standard) is the analytical standard of Terfenadine. This product is intended for research and analytical applications. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM . Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 .
Cat. No.: HY-P10145
CAS No.: 189684-49-9
Target:
Research Areas:
Cat. No.: HY-13205R
CAS No.: 273404-37-8
Synonyms: VX-765 (Standard)
Target:
Research Areas:
Belnacasan (Standard) is the analytical standard of Belnacasan. This product is intended for research and analytical applications. Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM .
Cat. No.: HY-P5122
CAS No.: 1135688-38-8
Target:
Research Areas:
Cat. No.: HY-P5955
CAS No.: 886462-82-4
Cat. No.: HY-182770
CAS No.: 3121390-12-0
Caspase-4-IN-1 (compound 35) is a selective allosteric caspase-4 inhibitor that spares caspase-1, and in embodiments acts as a dual caspase-4/5 inhibitor .
Cat. No.: HY-136727A
Cat. No.: HY-B1193S
CAS No.: 192584-82-0
Cat. No.: HY-112226R
CAS No.: 244133-31-1
Research Areas:
VRT-043198 (Standard) is the analytical standard of VRT-043198. This product is intended for research and analytical applications. VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively[1].
Cat. No.: HY-P81251
Synonyms: caspase-4 subunit 2; caspase-4 subunit p10; caspase-11; CASP-11; Protease ICH-3; Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP 4; CASP-4; CASP4; CASP4_HUMAN; CASP4_MOUSE; caspase 4 apoptosis related cysteine peptidase; caspase-4 subunit 2; caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; ICH 2 protease; ICH2; Mih1/TX; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease; EC:3.4.22.64.
Cat. No.: HY-P5956
CAS No.: 623948-42-5
Cat. No.: HY-L059
1,985 compounds
Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.
MCE designs a unique collection of 1,985 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
