2. Apoptosis
  3. Caspase
  4. Caspase-4-IN-1

Caspase-4-IN-1 (compound 35) is a selective allosteric caspase-4 inhibitor that spares caspase-1, and in embodiments acts as a dual caspase-4/5 inhibitor.

For research use only. We do not sell to patients.

Caspase-4-IN-1

Caspase-4-IN-1 Chemical Structure

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Caspase-4-IN-1 Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Caspase-4-IN-1 (compound 35) is a selective allosteric caspase-4 inhibitor that spares caspase-1, and in embodiments acts as a dual caspase-4/5 inhibitor[1].

IC50 & Target

Caspase-4

 

Parmacokinetics
Species Dose Route T1/2 Tmax Cmax MRT0-inf CL/F Vz/F AUC0-t AUC0-inf Bioavailability
Cynomolgus Monkey[1] 5 mg/kg p.o. 2.20 h 4 h 68.4 ng/mL 5.16 h 237 mL/min/kg 45.9 L/kg 386 ng·h/mL 402 ng·h/mL 4.03 %
Cynomolgus Monkey[1] 5 mg/kg p.o. 2.20 h 4 h 68.4 ng/mL 5.16 h 237 mL/min/kg 45.9 L/kg 386 ng·h/mL 402 ng·h/mL 4.03 %
Mice[1] 5 mg/kg p.o. 2.20 h 4 h 68.4 ng/mL 5.16 h 237 mL/min/kg 45.9 L/kg 386 ng·h/mL 402 ng·h/mL 4.03 %
Molecular Weight

519.95

Formula

C27H23ClFN5O3
SMILES

O=C1C2=C(C=C(C3=CC=CC(OC)=C3C#N)C=N2)N=C(C4=C(F)C=C(O[C@@H]5C[C@H](N)C5)C(Cl)=C4)N1CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Caspase-4-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Caspase-4-IN-1Caspasecaspase-4caspase-5caspase-1Inhibitorinhibitorinhibit

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