Caspase-4-IN-1
Caspase-4-IN-1 (compound 35) is a selective allosteric caspase-4 inhibitor that spares caspase-1, and in embodiments acts as a dual caspase-4/5 inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 3121390-12-0
- Formula: C27H23ClFN5O3
- Molecular Weight:519.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
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Caspase-4 |
| Species | Dose | Route | T1/2 | Tmax | Cmax | MRT0-inf | CL/F | Vz/F | AUC0-t | AUC0-inf | Bioavailability |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cynomolgus Monkey[1] | 5 mg/kg | p.o. | 2.20 h | 4 h | 68.4 ng/mL | 5.16 h | 237 mL/min/kg | 45.9 L/kg | 386 ng·h/mL | 402 ng·h/mL | 4.03 % |
| Cynomolgus Monkey[1] | 5 mg/kg | p.o. | 2.20 h | 4 h | 68.4 ng/mL | 5.16 h | 237 mL/min/kg | 45.9 L/kg | 386 ng·h/mL | 402 ng·h/mL | 4.03 % |
| Mice[1] | 5 mg/kg | p.o. | 2.20 h | 4 h | 68.4 ng/mL | 5.16 h | 237 mL/min/kg | 45.9 L/kg | 386 ng·h/mL | 402 ng·h/mL | 4.03 % |
Chemical Information
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CAS No. 3121390-12-0
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Molecular Weight 519.95
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Formula C27H23ClFN5O3
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SMILES
O=C1C2=C(C=C(C3=CC=CC(OC)=C3C#N)C=N2)N=C(C4=C(F)C=C(O[C@@H]5C[C@H](N)C5)C(Cl)=C4)N1CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Caspase-4-IN-1 Related Classifications
HY-182770 Related Classifications
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