Caspase-4-IN-1
Based on 1 Customer Validation
Caspase-4-IN-1 (compound 35) is a selective allosteric caspase-4 inhibitor that spares caspase-1, and in embodiments acts as a dual caspase-4/5 inhibitor.
For research use only. We do not sell to patients.
- Purity: 98.27%
- CAS No.: 3121390-12-0
- Formula: C27H23ClFN5O3
- Molecular Weight:519.95
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
All Caspase Isoforms
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Biological Activity
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Caspase-4 |
| Species | Dose | Route | T1/2 | Tmax | Cmax | MRT0-inf | CL/F | Vz/F | AUC0-t | AUC0-inf | Bioavailability |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cynomolgus Monkey[1] | 5 mg/kg | p.o. | 2.20 h | 4 h | 68.4 ng/mL | 5.16 h | 237 mL/min/kg | 45.9 L/kg | 386 ng·h/mL | 402 ng·h/mL | 4.03 % |
| Cynomolgus Monkey[1] | 5 mg/kg | p.o. | 2.20 h | 4 h | 68.4 ng/mL | 5.16 h | 237 mL/min/kg | 45.9 L/kg | 386 ng·h/mL | 402 ng·h/mL | 4.03 % |
| Mice[1] | 5 mg/kg | p.o. | 2.20 h | 4 h | 68.4 ng/mL | 5.16 h | 237 mL/min/kg | 45.9 L/kg | 386 ng·h/mL | 402 ng·h/mL | 4.03 % |
Chemical Information
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CAS No. 3121390-12-0
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Appearance Solid
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Molecular Weight 519.95
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Formula C27H23ClFN5O3
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Color Off-white to light yellow
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SMILES
O=C1C2=C(C=C(C3=CC=CC(OC)=C3C#N)C=N2)N=C(C4=C(F)C=C(O[C@@H]5C[C@H](N)C5)C(Cl)=C4)N1CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)