1. Membrane Transporter/Ion Channel
    Immunology/Inflammation
    GPCR/G Protein
    Neuronal Signaling
    Apoptosis
  2. Potassium Channel
    Histamine Receptor
    Na+/Ca2+ Exchanger
    Caspase
    Apoptosis
  3. Terfenadine-d3

Terfenadine-d3 

Cat. No.: HY-B1193S
Handling Instructions

Terfenadine-d3 ((±)-Terfenadine-d3) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.

For research use only. We do not sell to patients.

Terfenadine-d3 Chemical Structure

Terfenadine-d3 Chemical Structure

CAS No. : 192584-82-0

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Description

Terfenadine-d3 ((±)-Terfenadine-d3) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

474.69

Formula

C₃₂H₃₈D₃NO₂

CAS No.
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