192584-82-0
192584-82-0
Chemical Structure
Terfenadine-d3
- CAS 番号: 192584-82-0
- Formula:C32H38D3NO2
- Molecular Weight:474.69
IUPAC Name: 1-(4-(tert-butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1,2,2-d3-1-ol
InChIKey: GUGOEEXESWIERI-AKOBIBDASA-N
SMILES: C(O)(C1CCN(CCC(C(O)(C2=CC=C(C(C)(C)C)C=C2)[2H])([2H])[2H])CC1)(C3=CC=CC=C3)C4=CC=CC=C4
Biological Activity: Terfenadine-d3 ((±)-Terfenadine-d3) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Terfenadine-d3 | Terfenadine-d3 ((±)-Terfenadine-d3) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9. | |||||||||||||||||||||
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Terfenadine (Standard) | 99.91% | Terfenadine (Standard) is the analytical standard of Terfenadine. This product is intended for research and analytical applications. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9. | ||||||||||||||||||||
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Terfenadine | 99.98% | Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9. | ||||||||||||||||||||
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meta-Fexofenadine | 98.63% | meta-Fexofenadine (meta-MDL-16455) is an impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial. | ||||||||||||||||||||
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Fexofenadine Impurity F | Fexofenadine Impurity F is the impurity of Fexofenadine. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial. | |||||||||||||||||||||
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Terfenadine N-oxide | Terfenadine N-oxide, an N-oxide derivative of Terfenadine (HY-B1193), is a histamine H1 receptor antagonist (IC50 = 2.73 μM) and an hERG potassium channel inhibitor (IC50 = 0.698 μM). Terfenadine N-oxide is can be used for the research of histamine-related allergic diseases and hERG channel-associated arrhythmias. | |||||||||||||||||||||
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BFC220 | BFC220 is a covalent SARS-CoV-2 Mpro inhibitor with an IC50 of 2.77 μM. BFC220 can be used for antiviral research. | |||||||||||||||||||||
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Ebastine (Standard) | ≥98% | Ebastine (Standard) is the analytical standard of Ebastine. This product is intended for research and analytical applications. Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research. | ||||||||||||||||||||
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Fexofenadine | 99.84% | Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research. | ||||||||||||||||||||
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Fexofenadine hydrochloride (Standard) | ≥98% | Fexofenadine (hydrochloride) (Standard) is the analytical standard of Fexofenadine (hydrochloride). This product is intended for research and analytical applications. Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research. | ||||||||||||||||||||
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Fexofenadine-d6 | 99.28% | Fexofenadine-d6 (MDL-16455-d6) is deuterium labeled Fexofenadine, which is an antihistamine pharmaceutical agent. | ||||||||||||||||||||
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Fexofenadine-d6 Methyl Ester | Fexofenadine-d6 Methyl Ester is the deuterium labeled Fexofenadine Methyl Ester. | |||||||||||||||||||||
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