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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
co-chaperone
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "co-chaperone" in MCE Product Catalog:
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Target:
116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70 .
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Cat. No.: HY-P701386
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPBP1; Hsp70-Interacting Protein 2; HSPA (Hsp70) Binding Protein 1; Hsp70-Interacting Protein 1; FES1; Hsp70-Binding Protein 2; HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic cochaperone 1; HspBP2; Heat Shock Protein-Binding Protein 1; HspBP1; Hsp7
MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC) .
Cat. No.: HY-147125
CAS No.: 2640292-37-9
DDO-6600 is a covalent Hsp90 inhibitor. DDO-6600 disrupts the interaction between Hsp90 and its co-chaperone protein Cdc37, thereby inducing the degradation of kinase client proteins (such as AKT, CDK4, c-Raf). DDO-6600 has inhibitory activity against various cancer cells. DDO-6600 inhibits the migration and invasion of HCT-116 cells, and induces cell cycle arrest and apoptosis. DDO-6600 significantly inhibits tumor growth in the HCT-116 xenograft tumor model. DDO-6600 can be used for research on colorectal cancer .
Target:
Cat. No.: HY-19796R
CAS No.: 246529-22-6
Synonyms: Aramchol (Standard); C20-FABAC (Standard)
Research Areas:
Cucurbitacin D (Standard) is the analytical standard of Cucurbitacin D. This product is intended for research and analytical applications. Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .
Cat. No.: HY-P703390
Synonyms: HSCB; HscB Mitochondrial Iron-Sulfur Cluster co-chaperone; HscB Mitochondrial Iron-Sulfur Cluster cochaperone; HscB Iron-Sulfur Cluster co-chaperone Homolog; DNAJC20; Epididymis Secretory Sperm Binding Protein; HSC20; J-Type co-chaperone HSC20, Isoform CR
Cat. No.: HY-P75363
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDC37; CDC37 Cell Division Cycle 37 Homolog; Cell Division Cycle 37, HSP90 cochaperone; P50Cdc37; Hsp90 co-chaperone Cdc37; CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae); Hsp90 chaperone Protein Kinase-Targeting Subunit; Cell Division Cycle 37 Homo
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Cat. No.: HY-P75364
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDC37; CDC37 Cell Division Cycle 37 Homolog; Cell Division Cycle 37, HSP90 cochaperone; P50Cdc37; Hsp90 co-chaperone Cdc37; CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae); Hsp90 chaperone Protein Kinase-Targeting Subunit; Cell Division Cycle 37 Homo
Species:
Source:
Cat. No.: HY-P75362
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CDC37; CDC37 Cell Division Cycle 37 Homolog; Cell Division Cycle 37, HSP90 cochaperone; P50Cdc37; Hsp90 co-chaperone Cdc37; CDC37 Cell Division Cycle 37 Homolog (S. Cerevisiae); Hsp90 chaperone Protein Kinase-Targeting Subunit; Cell Division Cycle 37 Homo
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Cat. No.: HY-181062
VWK147 is a second-generation HSP90 C-terminal domain (CTD) inhibitor. VWK147 targets the CTD dimerization interface, prevents HSP90 CTD dimerization, disrupts co-chaperone PPID binding to HSP90 CTD, and inhibits HSP90 chaperone function dependent on dimerization. VWK147 reduces protein levels of HSP90 client proteins ULK1, RIPK1, and CDK4 without inducing a heat shock response. VWK147 induces cell death, including apoptosis, in Cisplatin (HY-17394)-sensitive and -resistant urothelial carcinoma cells. VWK147 induces LC3-II accumulation, inhibits autophagosome-lysosome fusion to block canonical autophagy, and induces non-canonical LC3 lipidation independent of ULK1 and PIK3C3 complexes. VWK147 can be used for the research of urothelial carcinoma .
Cat. No.: HY-P810989
Synonyms: EDJ; ERJ3; HDJ9; DnaJ homolog subfamily B member 11; APOBEC1-binding protein 2; ABBP-2; DnaJ protein homolog 9; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; Endoplasmic reticulum DNA J domain-containing protein 3; ER-resident protein ERdj3; ERdj3; ERj3p; HEDJ; Human DnaJ protein 9; hDj-9; PWP1-interacting protein 4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
