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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
conserved enzyme
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "conserved enzyme" in MCE Product Catalog:
Synonyms: APX001; E1211
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Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research .
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Hexokinase, Yeast is a hexokinase derived from yeast. Hexokinase, Yeast can be isolated from both fresh and dried baker's yeast. Hexokinases are evolutionarily conserved enzymes that phosphorylate six-carbon sugars (hexoses). Hexokinase prepares glucose for intracellular utilization. Hexokinase, Yeast is inhibited by 6-Deoxy-6-fluoroglucos .
Cat. No.: HY-P4279
CAS No.: 1370698-94-4
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Category:
Infection Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields
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Phosphoglucose Isomerase, Rabbit muscle (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .
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Nucleoside diphosphate kinase (Nucleoside 5′-diphosphate kinase) belongs to the family of structurally and functionally conserved NDPK (Nucleotide diphosphate kinase) enzymes. Nucleoside diphosphate kinase catalyzes the reversible transfer of γ-phosphates between nucleoside di-(NDP) and triphosphates (NTP) through ping-pong bi-bi reaction kinetics. Nucleoside diphosphate kinase is the essential housekeeping proteins that produces CTP (cytidine triphosphate) for lipid syntheses, UTP (Uridine triphosphate) for polysaccharide syntheses, and GTP (guanosine triphosphate) for protein syntheses, signal transduction, and microtubules polymerization .
Cat. No.: HY-146379
CAS No.: 2244991-17-9
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SARS-CoV-2-IN-19 (Compound 6g) is a potent inhibitor of SARS-CoV-2 with an EC50 of 8.8 μM. SARS-CoV-2-IN-19 shows potent activity against SARS-CoV-2 helicase (nsp13), a highly conserved enzyme, highlighting a potentiality against emerging HCoVs outbreaks. SARS-CoV-2-IN-19 has the potential for the research of infection diseases .
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Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .
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Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .
Cat. No.: HY-119726A
CAS No.: 1169701-00-1
Synonyms: APX001 (tautomerism); E1211 (tautomerism)
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Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections .
Cat. No.: HY-183076
CAS No.: 215778-00-0
AW00718 is a Brachyspira pilosicoli glutamate racemase (Bp-MurI) inhibitor. AW00718 binds to Bp-MurI active site residues, forming stable hydrogen bonds and interactions with conserved amino acids in the enzyme’s binding cavity. AW00718 exerts antibacterial and bactericidal activity against Brachyspira pilosicoli in vitro. AW00718 can be used for the research of intestinal spirochaetosis .
Cat. No.: HY-W1143867
CAS No.: 2226-71-3
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4’-Phosphopantetheine is an orally active coenzyme A (CoA) precursor. 4’-Phosphopantetheine is membrane-permeable and acts as a CoA precursor, a prosthetic group, and a reactive oxygen species (ROS) inhibitor. 4’-Phosphopantetheine binds covalently to rat liver fatty acid synthase, modifies the conserved serine residue in the PKS/NRPS carrier protein domain, and serves as a substrate for CoA synthase and PPAT. 4’-Phosphopantetheine undergoes non-catalytic exchange on rat liver fatty acid synthase, with a faster turnover rate than that of the enzyme complex, and restores intracellular CoA levels in cells with impaired de novo biosynthesis. 4’-Phosphopantetheine rescues phenotypes induced by CoA deficiency, normalizes PKAN-related biomarkers, restores mitochondrial enzyme activity, and alleviates vascular endothelial damage. 4’-Phosphopantetheine shows biological stability in serum, acts as a prosthetic group and degradation product of ACP, and inhibits the formation of atherosclerotic plaques. 4’-Phosphopantetheine can be used in the research of brain iron accumulation neurodegenerative diseases, pantothenate kinase-associated neurodegeneration, CoASY protein-associated neurodegenerative diseases, coronary heart disease, and atherosclerosis .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
