2. Anti-infection
  3. Bacterial
  4. AW00718

AW00718 is a Brachyspira pilosicoli glutamate racemase (Bp-MurI) inhibitor. AW00718 binds to Bp-MurI active site residues, forming stable hydrogen bonds and interactions with conserved amino acids in the enzyme’s binding cavity. AW00718 exerts antibacterial and bactericidal activity against Brachyspira pilosicoli in vitro. AW00718 can be used for the research of intestinal spirochaetosis.

For research use only. We do not sell to patients.

AW00718

AW00718 Chemical Structure

CAS No. : 215778-00-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

AW00718 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AW00718 is a Brachyspira pilosicoli glutamate racemase (Bp-MurI) inhibitor. AW00718 binds to Bp-MurI active site residues, forming stable hydrogen bonds and interactions with conserved amino acids in the enzyme’s binding cavity. AW00718 exerts antibacterial and bactericidal activity against Brachyspira pilosicoli in vitro. AW00718 can be used for the research of intestinal spirochaetosis[1].

In Vitro

AW00718 forms a stable complex with homology-modelled Brachyspira pilosicoli glutamate racemase (Bp-MurI)[1].
AW00718 (5 days) inhibits the growth of Brachyspira pilosicoli strain BP2904 in vitro with a MIC50 of 0.25 mM and a MIC100 of 0.5 mM[1].
AW00718 (1 mM; 24 h) causes ~20-25% cytotoxicity in human Chang conjunctival epithelial cells after 24 hours of treatment and 6 hours of Resazurin (HY-118540) exposure, with no cytotoxicity detected after 24 hours of Resazurin exposure[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AW00718 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human Chang conjunctival epithelial cells
Concentration: 1 mM
Incubation Time: 24 h following6 h (Resazurin exposure); 24 h (Resazurin exposure single)
Result: Induced ~20-25% cytotoxicity in human Chang conjunctival epithelial cells after 6 hours of Resazurin exposure.
Caused 0% cytotoxicity after 24 hours of resazurin single exposure.
Molecular Weight

385.28

Formula

C17H13BrN4S
CAS No.
SMILES

BrC1=CC=C(NC2=C3N=NC(SCC4=CC=C(C)C=C4)=N2)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AW00718 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AW00718215778-00-0AW 00718AW-00718BacterialBrachyspira pilosicoli strain BP2904Bp-MurIBrachyspira pilosicoliCYP isoenzymesBrachyspira pilosicoli glutamate racemaseintestinal spirochaetosisepithelial cellshuman Chang conjunctival epithelial cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AW00718
Cat. No.:
HY-183076
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.