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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
cooling
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "cooling" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: WS-12; AR-15512; AVX-012
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Research Areas:
Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .
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Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a "super-cooling agent" . Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response .
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1 Cited Publications
Cat. No.: HY-N8264
CAS No.: 73255-40-0
Category:
Natural Products Neurological Disease Moringa oleifera Lam. Moringaceae Plants Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-W127717
CAS No.: 51142-49-5
Synonyms: Perfluoro-compound FC-40
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ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents .
Cat. No.: HY-170505
CAS No.: 2254752-21-9
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Icafolin-methyl is a herbicide and plant β-tubulin (Microtubule/Tubulin) inhibitor. Icafolin-methyl binds to the β-tubulin region of the Colchicine (HY-16569) binding site, thereby blocking the polymerization of plant tubulin. As a non-selective herbicide, Icafolin-methyl exhibits post-emergence activity against weeds in both cool-season and warm-season cropping systems, including resistant ryegrass and darnel biotypes. Icafolin-methyl can be used for herbicide research .
Cat. No.: HY-W423502
CAS No.: 68489-14-5
Synonyms: Menthane carboxamidoethyl acetate
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WS5 (Menthane carboxamidoethyl acetate) is a cooling agent fragrance ingredient .
Cat. No.: HY-N1369S
CAS No.: 1217765-02-0
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FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception .
Cat. No.: HY-108449S
Synonyms: WS-12-d3; AR-15512-d3; AVX-012-d3
Cat. No.: HY-N1369S1
CAS No.: 1335435-38-5
Cat. No.: HY-117372
CAS No.: 1445753-16-1
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DFL23448 is a selective transient receptor potential melastatin-8 (TRPM8) antagonist. DFL23448 shows IC50 values of 10 and 21 nM in hTRPM8 human embryonic kidney 293 cells activated by Cooling Agent 10 or cold. DFL23448 has limited activity (IC50 >10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors. DFL23448 can modify bladder function and reduce bladder overactivity in awake rats .
Cat. No.: HY-108449R
CAS No.: 68489-09-8
Synonyms: WS-12 (Standard); AR-15512 (Standard); AVX-012 (Standard)
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Research Areas:
Acoltremon (Standard) is the analytical standard of Acoltremon (HY-108449). This product is intended for research and analytical applications. Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
