36945-98-9
36945-98-9
Chemical Structure
Icilin
Synonym(s): AG-3-5
- CAS No.: 36945-98-9
- Formula:C16H13N3O4
- Molecular Weight:311.29
IUPAC Name: 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one
InChIKey: RCEFMOGVOYEGJN-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=CC=C2O)CC=C(C3=CC=CC([N+]([O-])=O)=C3)N1
Biological Activity: Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a "super-cooling agent" [1][2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Icilin | 99.26% | Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a "super-cooling agent" . Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response. | ||||||||||||||||||||
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Icilin (Standard) | ≥98% | Icilin (Standard) is the analytical standard of Icilin (HY-11062). This product is intended for research and analytical applications. Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a "super-cooling agent" . Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response. | ||||||||||||||||||||
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RTC14 | RTC14 is a read-through compound (RTC) that can induce ribosomes to bypass nonsense mutations in mRNA and allow the production of full-length functional proteins. RTC14 has the potential to be used in the research of various genetic disorders, such as nonsense mutations in the ataxia-telangiectasia mutated (ATM) gene and the dystrophin gene. | |||||||||||||||||||||
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DJ001 | 99.92% | DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC50 of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration. | ||||||||||||||||||||
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TMBIM6 antagonist-1 | 98.92% | TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca2+. | ||||||||||||||||||||
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CXCR2 antagonist 8 | 98.38% | CXCR2 antagonist 8 is a potent and selective CXCR2 antagonist. CXCR2 antagonist 8 can be used for insulin resistance research. | ||||||||||||||||||||
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Anticancer agent 252 | Anticancer agent 252 (compound 1) is a benzamide compound with selective anti-cancer activity against small cell lung cancer (SCLC) cells. Anticancer agent 252 inhibits murine SCLC (mSCLC) cell lines with an average EC50 of 3.21 μM. Anticancer agent 252 also inhibits human SCLC cell lines, H889, H2107, and H128. | |||||||||||||||||||||
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GW9662 (Standard) | ≥98% | GW9662 (Standard) is the analytical standard of GW9662. This product is intended for research and analytical applications. GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively. | ||||||||||||||||||||
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SB225002 | 99.90% | SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM. | ||||||||||||||||||||
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2-Amino-5-nitrobenzophenone | 98.43% | 2-Amino-5-nitrobenzophenone (Ro-7-19990) is a degradation of benzodiazepines. 2-Amino-5-nitrobenzophenone can be used for research and forensic applications. | ||||||||||||||||||||
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Naphthol AS-BS | 99.12% | Naphthol AS-BS (Compound 1) is a human cytomegalovirus (HCMV) DNA polymerase alpha inhibitor with an IC50 of 12 μM. Naphthol AS-BS can be used for the research of infection. | ||||||||||||||||||||
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Nimesulide impurity 7 | Nimesulide impurity 7 (4-Nitro-2-phenoxyphenol) is an impurity of Nimesulide. | |||||||||||||||||||||
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References
- [1]. Huai-hu Chuang, et al. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron. 2004 Sep 16;43(6):859-69. [Content Brief]
- [2]. Viktor V Feketa,et al. Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. Crit Care Med. 2014 May;42(5):e355-63. [Content Brief]
- [3]. Benjamin W Ewanchuk, et al. The cooling compound icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response. FASEB J. 2018 Mar;32(3):1236-1249. [Content Brief]
