2. Cell Cycle/DNA Damage Cytoskeleton Metabolic Enzyme/Protease
  3. Microtubule/Tubulin Herbicide
  4. Icafolin-methyl

Icafolin-methyl is a herbicide and plant β-tubulin (Microtubule/Tubulin) inhibitor. Icafolin-methyl binds to the β-tubulin region of the Colchicine (HY-16569) binding site, thereby blocking the polymerization of plant tubulin. As a non-selective herbicide, Icafolin-methyl exhibits post-emergence activity against weeds in both cool-season and warm-season cropping systems, including resistant ryegrass and darnel biotypes. Icafolin-methyl can be used for herbicide research.

For research use only. We do not sell to patients.

Icafolin-methyl

Icafolin-methyl Chemical Structure

CAS No. : 2254752-21-9

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Based on 1 publication(s) in Google Scholar

Icafolin-methyl Related Antibodies

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Description

Icafolin-methyl is a herbicide and plant β-tubulin (Microtubule/Tubulin) inhibitor. Icafolin-methyl binds to the β-tubulin region of the Colchicine (HY-16569) binding site, thereby blocking the polymerization of plant tubulin. As a non-selective herbicide, Icafolin-methyl exhibits post-emergence activity against weeds in both cool-season and warm-season cropping systems, including resistant ryegrass and darnel biotypes. Icafolin-methyl can be used for herbicide research[1].

In Vitro

Icafolin-methyl (10 nM; 2 weeks) strongly inhibits Arabidopsis thaliana Col-0 seedling growth, inducing morphological abnormalities consistent with mitotic disruption[1].
Icafolin-methyl (100 nM; 3 days) inhibits tobacco BY-2 cell replication, induces isodiametric cell swelling, and disrupts chromatin structure, indicating mitotic disruption via tubulin polymerization inhibition[1].
Icafolin-methyl (1.6 μM; 3 days) inhibits Chlamydomonas reinhardtii CC1690 mt+ cell growth with an EC50 of 1.3 ± 0.1 μM, preventing cell division and inducing massive cell swelling consistent with tubulin polymerization inhibition[1].
Icafolin-methyl (10 μM; throughout tubulin polymerization reaction) potently inhibits the in vitro polymerization of purified tobacco BY-2 tubulin, confirming its mode of action as a tubulin polymerization inhibitor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Icafolin-methyl Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Tobacco BY-2 suspension cell
Concentration: 100 nM
Incubation Time: 3 days
Result: Stopped cell replication.
Induced isodiametric cell swelling.
Caused fragmented, dispersed DAPI-stained chromatin, consistent with tubulin polymerization inhibitor activity.

Cell Proliferation Assay[1]

Cell Line: Chlamydomonas reinhardtii CC1690 mt+ cell
Concentration: 1.6 μM; tested for EC50 determination
Incubation Time: 3 days
Result: Inhibited cell growth with an EC50 of 1.3 μM.
Prevented cell division.
Induced extreme cell swelling (up to ~300-fold larger volume than untreated cells).
Molecular Weight

380.34

Formula

C18H18F2N2O5
CAS No.
SMILES

COC([C@H](OC1)C[C@H]1NC([C@]2(CC(C3=CC(F)=CC(F)=C3)=NO2)C=C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Icafolin-methyl Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Icafolin-methyl2254752-21-9Microtubule/TubulinHerbicideherbicideplant β-tubulin inhibitorBY-2 cellArabidopsis thalianaChlamydomonas reinhardtiiInhibitorinhibitorinhibit

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