2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. FEMA 4809

FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception.

For research use only. We do not sell to patients.

FEMA 4809 Chemical Structure

FEMA 4809 Chemical Structure

CAS No. : 1374760-95-8

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Description

FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception[1].

Molecular Weight

327.40

Formula

C17H17N3O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N(C1=NNC=C1)CC2=CC=CS2)COC3=CC=C(C)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (763.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0544 mL 15.2718 mL 30.5437 mL
5 mM 0.6109 mL 3.0544 mL 6.1087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0544 mL 15.2718 mL 30.5437 mL 76.3592 mL
5 mM 0.6109 mL 3.0544 mL 6.1087 mL 15.2718 mL
10 mM 0.3054 mL 1.5272 mL 3.0544 mL 7.6359 mL
15 mM 0.2036 mL 1.0181 mL 2.0362 mL 5.0906 mL
20 mM 0.1527 mL 0.7636 mL 1.5272 mL 3.8180 mL
25 mM 0.1222 mL 0.6109 mL 1.2217 mL 3.0544 mL
30 mM 0.1018 mL 0.5091 mL 1.0181 mL 2.5453 mL
40 mM 0.0764 mL 0.3818 mL 0.7636 mL 1.9090 mL
50 mM 0.0611 mL 0.3054 mL 0.6109 mL 1.5272 mL
60 mM 0.0509 mL 0.2545 mL 0.5091 mL 1.2727 mL
80 mM 0.0382 mL 0.1909 mL 0.3818 mL 0.9545 mL
100 mM 0.0305 mL 0.1527 mL 0.3054 mL 0.7636 mL
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FEMA 4809 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FEMA 48091374760-95-8FEMA4809FEMA-4809TRP ChannelTransient receptor potential channelsTRPM8 receptor agonistcooling agention channelcool perceptionInhibitorinhibitorinhibit

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