224 Results for "

cyclobutane

" in MedChemExpress (MCE) Product Catalog:
Products (224)

224 Results for "cyclobutane" in MCE Product Catalog:

29
Cyclo(-RGDfK)
Cyclo(-RGDfK)
0 Images
29 Publications Verification
Cat. No.: HY-P0023
CAS No.: 161552-03-0
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
29
Cyclo(-RGDfK) TFA
Cyclo(-RGDfK) TFA
0 Images
29 Publications Verification
Cat. No.: HY-P0023A
CAS No.: 500577-51-5
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
16
Alisporivir
Alisporivir
0 Images
16 Cited Publications
Cat. No.: HY-12559
CAS No.: 254435-95-5
Purity:  98.08%
Synonyms: Debio-025; DEB-025
Target:  

Cyclophilin HCV

Research Areas:  

Infection

Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.
7
Cyclo(Phe-Pro)
Cyclo(Phe-Pro)
0 Images
7 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Target:  

HCV Bacterial Antibiotic Reactive Oxygen Species (ROS)

Research Areas:  

Infection

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .
4
Cyclo(RGDyK)
Cyclo(RGDyK)
0 Images
4 Cited Publications
Cat. No.: HY-100563A
CAS No.: 217099-14-4
Purity:  99.83%
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
4
Cyclo(RGDyK) trifluoroacetate
Cyclo(RGDyK) trifluoroacetate
0 Images
4 Cited Publications
Cat. No.: HY-100563
CAS No.: 250612-42-1
Purity:  99.92%
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
4
BQ-123
BQ-123
0 Images
4 Cited Publications
Cat. No.: HY-12378
CAS No.: 136553-81-6
Purity:  99.82%
Target:  

Endothelin Receptor

Research Areas:  

Cardiovascular Disease

BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .
3
Astressin
Astressin
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3 Cited Publications
Cat. No.: HY-P0257
CAS No.: 170809-51-5
Target:  

CRFR

Research Areas:  

Neurological Disease

Astressin is a potent corticotropin releasing factor (CRF) antagonist.
3
Murepavadin TFA
Murepavadin TFA
0 Images
3 Cited Publications
Cat. No.: HY-P1674A
CAS No.: 3053070-05-3
Synonyms: POL7080 TFA
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance .
2
Cyclo(Arg-Gly-Asp-D-Phe-Cys)
Cyclo(Arg-Gly-Asp-D-Phe-Cys)
0 Images
2 Cited Publications
Cat. No.: HY-P2300
CAS No.: 862772-11-0
Synonyms: Cyclo(RGDfC)
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .
2
Segetalin B
Segetalin B
0 Images
2 Cited Publications
Cat. No.: HY-107245
CAS No.: 164991-89-3
Purity:  99.51%
Category:  

Vaccaria segetalis (Neck.) Garcke Cyclopeptides Metabolic Disease Plants Disease Research Fields Caryophyllaceae

Target:  

Estrogen Receptor/ERR Sirtuin RUNX

Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) .
2
AZP-531
AZP-531
0 Images
2 Cited Publications
Cat. No.: HY-P0231
CAS No.: 1088543-62-7
Target:  

GHSR

Research Areas:  

Metabolic Disease Endocrinology

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
2
cyclo(RLsKDK)
cyclo(RLsKDK)
0 Images
2 Cited Publications
Cat. No.: HY-P1676
CAS No.: 1975145-82-4
Synonyms: BK-1361
Target:  

MMP

Research Areas:  

Cancer

cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) has potential applications in inflammatory diseases and cancer .
2
cyclo(RLsKDK) TFA
cyclo(RLsKDK) TFA
0 Images
2 Cited Publications
Cat. No.: HY-P1676A
Synonyms: BK-1361 TFA
Target:  

MMP

Research Areas:  

Cancer

cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer .
1
Gramicidin S
Gramicidin S
0 Images
1 Cited Publications
Cat. No.: HY-P5712
CAS No.: 113-73-5
Synonyms: Gramicidin soviet
Target:  

Antibiotic Bacterial Na+/K+ ATPase

Research Areas:  

Infection

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
1
Cyclo(Gly-Tyr)
Cyclo(Gly-Tyr)
0 Images
1 Cited Publications
Cat. No.: HY-131109
CAS No.: 5845-66-9
Purity:  99.70%
Target:  

Peptides

Research Areas:  

Others

Cyclo(Gly-Tyr) is a cyclic dipeptide .
1
Cyclo(RADfK)
Cyclo(RADfK)
0 Images
1 Cited Publications
Cat. No.: HY-P0031
CAS No.: 756500-23-9
Target:  

Integrin

Research Areas:  

Others

Cyclo(RADfK) can be used as a control for Cyclo(-RGDfK) (HY-P0023) .
1
Cyclosomatostatin
Cyclosomatostatin
0 Images
1 Cited Publications
Cat. No.: HY-P1201
CAS No.: 84211-54-1
Target:  

Somatostatin Receptor

Research Areas:  

Cancer

Cyclosomatostatin is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells .
1
Balixafortide
Balixafortide
0 Images
1 Cited Publications
Cat. No.: HY-P1682
CAS No.: 1051366-32-5
Synonyms: POL6326
Target:  

CXCR Arrestin

Research Areas:  

Cancer

Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .
1
Balixafortide TFA
Balixafortide TFA
0 Images
1 Cited Publications
Cat. No.: HY-P1682A
Synonyms: POL6326 TFA
Target:  

CXCR Arrestin

Research Areas:  

Cancer

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .
Assay Types