84211-54-1
Chemical Structure
Cyclosomatostatin
- CAS No.: 84211-54-1
- Formula:C44H57N7O6
- Molecular Weight:779.97
IUPAC Name: (3S,6S,9R,12S)-9-((1H-indol-3-yl)methyl)-6-(4-aminobutyl)-12-benzyl-3-((R)-1-(benzyloxy)ethyl)-1,4,7,10,13-pentaazacycloicosane-2,5,8,11,14-pentaone
InChIKey: YHVHQZYJGWGAKN-ZUWUZHNASA-N
SMILES: O=C(N[C@@](C(N[C@@]1([H])[C@@H](C)OCC2=CC=CC=C2)=O)([H])CCCCN)[C@H](NC([C@@H](NC(CCCCCCNC1=O)=O)CC3=CC=CC=C3)=O)CC4=CNC5=C4C=CC=C5
Biological Activity: Cyclosomatostatin is a non-selective somatostatin receptor antagonist that blocks SSTR1-5-mediated signaling. Cyclosomatostatin decreases the ALDH+ stem cell population and sphere formation without affecting cell viability, and reduces cell proliferation. Cyclosomatostatin activates opioid receptors. Cyclosomatostatin can be used for research on arthritis and colorectal cancer[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cyclosomatostatin | 99.56% | Cyclosomatostatin is a non-selective somatostatin receptor antagonist that blocks SSTR1-5-mediated signaling. Cyclosomatostatin decreases the ALDH+ stem cell population and sphere formation without affecting cell viability, and reduces cell proliferation. Cyclosomatostatin activates opioid receptors. Cyclosomatostatin can be used for research on arthritis and colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Heppelmann B, et al. Peripheral application of cyclo-somatostatin, a somatostatin antagonist, increases the mechanosensitivity of rat knee joint afferents. Neuroscience letters. 1999 Jan 04;259(1):62-4.
- [2]. Modarai SR, et al. Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells. BMC cancer. 2016 Dec 07;16(1):941. [Content Brief]
- [3]. Wenzel U, et al. Cyclic somatostatin analogs bind specifically to pI 6.1 carboxylesterase of rat liver cells. Biochemical pharmacology. 1995 Feb 14;49(4):479-87.
- [4]. Benko R, et al. The putative somatostatin antagonist cyclo-somatostatin has opioid agonist effects in gastrointestinal preparations. Life sciences. 2012 May 22;90(19-20):728-32.
- [5]. Brockway DF, et al. Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior. Cell reports. 2023 Aug 29;42(8):112976.
- [6]. Racine AS, et al. Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons. Molecular brain. 2021 Aug 24;14(1):130.
