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digoxin

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By Targets:	Biochemical Assay Reagents (5) Calcium Channel (1) CCR (1) Drug Isomer (1) Drug Metabolite (2) Endogenous Metabolite (1) Environmental Pollutants (1) Interleukin Related (4) Na+/K+ ATPase (8) P-glycoprotein (1) Potassium Channel (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (5) Inflammation/Immunology (7) Metabolic Disease (2)

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Biochemical Assay Reagents

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Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0344D

Sodium chloride, for cell culture 3 Publications Verification Halite, for cell culture	Environmental Pollutants Biochemical Assay Reagents Interleukin Related Na+/K+ ATPase	Inflammation/Immunology Cancer
Sodium chloride, for cell culture is an orally active salt. Sodium chloride, for cell culture induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, for cell culture enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, for cell culture drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-Y0344J

Sodium chloride, for molecular biology 3 Publications Verification Halite, for molecular biology	Biochemical Assay Reagents Na+/K+ ATPase Interleukin Related	Inflammation/Immunology Cancer
Sodium chloride is an orally active salt. Sodium chloride induces the expression of ATP1A1. Sodium chloride induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-Y0344I

Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al 3 Publications Verification Halite, meets analytical specification of Ph. Eur. BP USP	Biochemical Assay Reagents Na+/K+ ATPase Interleukin Related	Inflammation/Immunology Cancer
Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt is an orally active salt. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the expression of ATP1A1. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-145154

Digoxigenin monodigitoxoside	Na+/K+ ATPase Drug Metabolite	Cardiovascular Disease Metabolic Disease
Digoxigenin monodigitoxoside, a metabolite of Digoxin (HY-B1049), belongs to the class of cardenolides. Digoxigenin monodigitoxoside exerts its function by inhibiting Na,K-ATPase. Digoxigenin monodigitoxoside is used for the research of cardiovascular diseases such as congestive heart failure and cardiac arrhythmias .

HY-136933

Gitoxin	Na+/K+ ATPase	Cardiovascular Disease
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure .

HY-161533

Digoxin/BSA	Biochemical Assay Reagents	Inflammation/Immunology
Digoxin/BSA is an antigen-adjuvant conjugate of Digoxin (HY-B1049) and Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.

HY-119101

AZD-5672 1 Publications Verification	CCR Potassium Channel P-glycoprotein	Inflammation/Immunology
AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC₅₀=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC₅₀=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC₅₀=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis .

HY-158292

Digoxin-OVA	Endogenous Metabolite Na+/K+ ATPase	Inflammation/Immunology
Digoxin-OVA is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-Y0344H

Sodium chloride, United States Pharmacopeia (USP) Reference Standard Halite (Pharmaceutical primary standard, USP)	Biochemical Assay Reagents Na+/K+ ATPase Interleukin Related	Inflammation/Immunology Cancer
Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-15718B

Istaroxime oxalate PST2744 oxalate	Na+/K+ ATPase	Cardiovascular Disease
Istaroxime oxalate (PST2744 oxalate) is the oxalate form of Istaroxime (HY-15718). Istaroxime oxalate is is an inotropic agent, that inhibits Na ⁺/K ⁺-ATPase with an IC₅₀ of 0.11 μM. Istaroxime oxalate increases force of contraction in guinea pig atria and twitch amplitude in isolated guinea pig myocytes without causing lethal arrhythmias .

HY-178082

MK-251	Others	Cardiovascular Disease
MK-251 is an orally active anti-arrhythmic agent. MK-251 prevents or modifies ventricular arrhythmias induced in dogs and baboons by tetrafluorethylbutylamine. MK-251 antagonizes the arrhythmias caused by Digoxin (HY-B1049) in cats. MK-251 at effective doses has little effect on basic cardiovascular parameters such as blood pressure, cardiac output, myocardial contractility and ventricular conduction, thus demonstrating its unique advantages .

HY-136677

Lnd 796	Calcium Channel	Cardiovascular Disease
LND 796 is an aminosteroidal derivative with positive inotropic effects similar to those of digitalis. It exhibits electrophysiological, toxic, and inotropic effects in normal and partially potassium-depolarized ventricular muscles. LND 796 requires higher concentrations than digoxin to induce the same toxic symptoms. It exhibits a concentration-dependent positive inotropic effect on guinea pig papillary muscles in normal potassium solution. In partially potassium-depolarized papillary muscles, LND 796 enhances both components of contraction and increases the amplitude of slow action potentials. The mechanism of positive inotropic action of LND 796 involves enhanced calcium entry in calcium channels and inhibition of sodium-potassium ATPase. Due to its expanded positive inotropic range, LND 796 may have potential application in the treatment of congestive heart failure.

HY-182475

SQ 31906 free base	Drug Metabolite Drug Isomer	Metabolic Disease
SQ 31906 free base is the 3α-hydroxy isomer and metabolite of Pravastatin (HY-B0165). SQ 31906 free base forms via non-enzymatic reaction under acidic conditions. Pravastatin is used in hypercholesterolemia research .

Cat. No.	Product Name	Type

HY-Y0344D

Sodium chloride, for cell culture 3 Publications Verification Halite, for cell culture	Biochemical Assay Reagents
Sodium chloride, for cell culture is an orally active salt. Sodium chloride, for cell culture induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, for cell culture enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, for cell culture drives autoimmune disease by the induction of pathogenic Th17 cells .

Sodium chloride, for cell culture

3 Publications Verification

Halite, for cell culture

Biochemical Assay Reagents

Sodium chloride, for cell culture is an orally active salt. Sodium chloride, for cell culture induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, for cell culture enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, for cell culture drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-Y0344J

Sodium chloride, for molecular biology 3 Publications Verification Halite, for molecular biology	Biochemical Assay Reagents
Sodium chloride is an orally active salt. Sodium chloride induces the expression of ATP1A1. Sodium chloride induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride drives autoimmune disease by the induction of pathogenic Th17 cells .

Sodium chloride, for molecular biology

3 Publications Verification

Halite, for molecular biology

Biochemical Assay Reagents

Sodium chloride is an orally active salt. Sodium chloride induces the expression of ATP1A1. Sodium chloride induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-Y0344I

Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al 3 Publications Verification Halite, meets analytical specification of Ph. Eur. BP USP	Biochemical Assay Reagents
Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt is an orally active salt. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the expression of ATP1A1. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt drives autoimmune disease by the induction of pathogenic Th17 cells .

Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al

3 Publications Verification

Halite, meets analytical specification of Ph. Eur. BP USP

Biochemical Assay Reagents

Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt is an orally active salt. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the expression of ATP1A1. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt drives autoimmune disease by the induction of pathogenic Th17 cells .

HY-161533

Digoxin/BSA	Biochemical Assay Reagents
Digoxin/BSA is an antigen-adjuvant conjugate of Digoxin (HY-B1049) and Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.

HY-158292

Digoxin-OVA	Biochemical Assay Reagents
Digoxin-OVA is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-Y0344H

Sodium chloride, United States Pharmacopeia (USP) Reference Standard Halite (Pharmaceutical primary standard, USP)	Biochemical Assay Reagents
Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells .

Sodium chloride, United States Pharmacopeia (USP) Reference Standard

Halite (Pharmaceutical primary standard, USP)

Biochemical Assay Reagents

Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an orally active salt. Sodium chloride, United States Pharmacopeia (USP) Reference Standard induces the expression of ATP1A1. Sodium chloride, for cell culture induces the pro-inflammatory cytokines IL-2, TNFα, IL-9 and several chemokines. Sodium chloride, United States Pharmacopeia (USP) Reference Standard enhances the anti-tumor activities of Digoxin (HY-B1049) against small cell lung cancer. Sodium chloride, United States Pharmacopeia (USP) Reference Standard drives autoimmune disease by the induction of pathogenic Th17 cells .

Gitoxin	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Na+/K+ ATPase
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na ⁺/K ⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure .

Host:	Mouse (1) Rabbit (1)
Reactivity:	Species independent (1)
Application:	IHC-P (1) IF-Tissue (1) IP (1) DotBlot (1) IHC-F (1) WB (1) ELISA (2)
Isotype:	IgG (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85752

	Digoxin Antibody (YA5444)	ELISA
	Digoxin Antibody (YA5444) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Digoxin.

HY-P86852

	Digoxin Antibody (YA6545) 1672-46-4 antibody; BRN 0096479 antibody; DIG antibody; EINECS 216-806-2 antibody; HSDB 7108 antibody; Lanadigenin antibody; Lanadigigenin antibody; ST056392 antibody; Digoxigenin 地高辛	WB, ELISA, IHC-P, IHC-F, DotBlot, IF-Tissue, IP	Species independent
	Digoxin Antibody (YA6545) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Digoxin.

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digoxin

Inhibitors & Agonists

Biochemical Assay Reagents

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Antibodies

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