Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
dopamine autoreceptor
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "dopamine autoreceptor" in MCE Product Catalog:
Synonyms: (-)-3-PPP hydrochloride
Target:
Research Areas:
Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective dopamine autoreceptor agonist. Preclamol hydrochloride has the potential for the research of schizophrenia .
Synonyms: GR 205171A
Target:
Research Areas:
Vofopitant dihydrochloride (GR 205171A) is a blood-brain barrier-permeable NK1 receptor inhibitor with a pKi of 9.02 in mice. Vofopitant dihydrochloride blocks vomiting-related responses and inhibits pseudoptyalism. Vofopitant dihydrochloride exerts anxiolytic effects, regulates 5-HT receptor function and increases central 5-HT release. Vofopitant dihydrochloride improves hyperarousal symptoms of post-traumatic stress disorder. Vofopitant dihydrochloride can be used in research related to depression, anxiety, vomiting and postoperative nausea and vomiting .
Target:
Research Areas:
NMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine.
Target:
Research Areas:
CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research .
Synonyms: EMD 38362
Research Areas:
Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities .
Synonyms: (+)-3-PPP
Target:
Research Areas:
(R)-Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. (R)-Preclamol inhibits the locomotor activity of mice and rats in low doses .
Synonyms: (+)-AJ 76 hydrochloride; (1S,2R)-AJ 76 hydrochloride
Target:
Research Areas:
AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) is an antagonist of dopamine autoreceptor with pKi values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hD3, hD4, hD2S, hD2L and rD2 receptors, respectively.
Cat. No.: HY-106781
CAS No.: 111073-34-8
Target:
Research Areas:
OPC-4392 is a orally active presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models. OPC-4392 can be used as antipsychotic agent .
Cat. No.: HY-105447
CAS No.: 115688-97-6
Target:
Research Areas:
PD 128483 is a selective dopamine autoreceptor agonist. PD 128483 can be used for the research of neurological disease .
Cat. No.: HY-111283
CAS No.: 85379-09-5
Synonyms: (+)-AJ 76; (1S,2R)-AJ 76
Target:
Research Areas:
AJ-76 ((+)-AJ 76; (1S,2R)-AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor .
Cat. No.: HY-145454A
CAS No.: 85966-89-8
Synonyms: (-)-3-PPP
Target:
Research Areas:
Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. Preclamol inhibits the locomotor activity of mice and rats in low doses .
Cat. No.: HY-118402
CAS No.: 105277-43-8
Target:
Research Areas:
PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis .
Cat. No.: HY-100539
CAS No.: 123594-64-9
Target:
Research Areas:
PD 128907 is a D3 receptor ligand with activities of activating dopamine receptors, inhibiting cell firing, and inhibiting dopamine release. The active (+) enantiomer of PD 128907 has high affinity and selectivity for rat D3 dopamine receptors. PD 128907 inhibits cell firing in the ventral tegmental area and substantia nigra pars compacta with EC50 values of 33nM and 38nM, respectively. PD 128907 also inhibits dopamine release in the caudate putamen with an EC50 of 66nM. However, the selective D2 receptor antagonist L-741,626 has high affinity for receptors activated by PD 128907, indicating that the effects of PD 128907 are more likely on D2 autoreceptors rather than D3 dopamine receptor subtypes.
Cat. No.: HY-106100
CAS No.: 112192-04-8
Synonyms: EMD 49980
Research Areas:
Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor. Antipsychotic and antidepressant activities .
Cat. No.: HY-114578
CAS No.: 104229-37-0
Target:
Research Areas:
PD 118717 is a selective dopamine (DA) D-2 autoreceptor agonist. PD 118717 has significant affinity for 5-HT1A but not 5-HT1B and 5-HT2 receptors. PD 118717 is active in antagonizing the tau-Butyrolactone-induced accumulation of dopa in rat striatum and mesolimbic regions. PD 118717 exhibits an antipsychotic-like profile .
Cat. No.: HY-106100AR
CAS No.: 108050-82-4
Synonyms: EMD 38362 (Standard)
Research Areas:
Roxindole (hydrochloride) (Standard) is the analytical standard of Roxindole (hydrochloride). This product is intended for research and analytical applications. Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities .
Cat. No.: HY-N7007R
CAS No.: 55881-96-4
Category:
Target:
Cat. No.: HY-145454B
CAS No.: 75240-91-4
Synonyms: (±)-3-PPP
Target:
Research Areas:
(Rac)-Preclamol ((±)-3-PPP) is the racemate of (R)-Preclamol (HY-145454A) and Preclamol (HY-145454A). (Rac)-Preclamol exhibits autoreceptor agonistic activity at dopamine Dopamine Receptor, with almost no effect on postsynaptic dopamine receptors. (Rac)-Preclamol inhibits spontaneous motor activity and the γ-butyrolactone-induced increase in mature striatal Tyrosine Hydroxylase activity. (Rac)-Preclamol can be used in research related to neurological diseases .
Cat. No.: HY-101540R
CAS No.: 129024-87-9
Target:
Research Areas:
NMI 8739 (Standard) is the analytical standard of NMI 8739 (HY-101540). This product is intended for research and analytical applications. NMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine.
Cat. No.: HY-169837
CAS No.: 163239-24-5
Research Areas:
PD-147693 (compound II) is an active metabolite of the presynaptic dopamine autoreceptor agonist CI-1007 and has antipsychotic activity similar to CI-1007 .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
