1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. CGP 25454A

CGP 25454A 

Cat. No.: HY-100454 Purity: 99.46%
Handling Instructions

CGP 25454A is a novel and selective presynaptic dopamine autoreceptor antagonist.

For research use only. We do not sell to patients.

CGP 25454A Chemical Structure

CGP 25454A Chemical Structure

CAS No. : 104391-26-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 320 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 720 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Description

CGP 25454A is a novel and selective presynaptic dopamine autoreceptor antagonist. In vitro: CGP 25454A increase the field-stimulated [3H]- and [14C]-overflow from rat striatal slices preloaded with [3H]dopamine and [14C]choline, indicating that CGP 25454A is able to enhance the release of both dopamine (DA) and acetylcholine (ACh). However, CGP 25454A is 12.9 times more potent in increasing, by 1/6 of the apparent maximal increase, the release of [3H]DA than that of [14C]ACh. In vivo: CGP 25454A increase [3H]spiperone binding to receptors of the D2 family in rat striatum by 90-110% (ED50: 13 mg/kg i.p.). As a similar increase in [3H]spiperone binding is found with a variety of agents which increase the synaptic concentration of endogenous DA, the effect of CGP 25454A most probably reflects an enhanced release of DA under in vivo conditions. At 30-100 mg/kg, CGP 25454A inhibit [3H]spiperone binding in the pituitary of the same animals as a result of a blockade of postsynaptic DA receptors.

Molecular Weight

346.25

Formula

C₁₅H₂₁Cl₂N₃O₂

CAS No.

104391-26-6

SMILES

O=C(NCCN(CC)CC)C1=CC(C#N)=C(Cl)C=C1OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 3.5 mg/mL (10.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8881 mL 14.4404 mL 28.8809 mL
5 mM 0.5776 mL 2.8881 mL 5.7762 mL
10 mM 0.2888 mL 1.4440 mL 2.8881 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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CGP 25454A
Cat. No.:
HY-100454
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