CGP 25454A
Based on 1 Customer Validation
CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research.
For research use only. We do not sell to patients.
- Purity: 99.65%
- CAS No.: 104391-26-6
- Formula: C15H21Cl2N3O2
- Molecular Weight:346.25
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CGP 25454A (0.5-10 μM, 15 min) elicits a reproducible and concentration-dependent increase of the release of both DA and ACh in rat striatal slices with an increase by 62±3% and 100±7% at 10 μM. CGP 25454A is 12.9 fold more potent at pre- than post-synaptic DA receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CGP 25454A (0.5-100 mg/kg, i.p., 10-60 min) exerts opposite effects with a slight behavioral stimulation at low doses and a clear-cut central depressant action in the higher dose range[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Tif rats with Amphetamine-induced hyperactivity[1]
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Dosage:0.5-100 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Did not modify ambulation but increased rearing at 2.5 and 10mg/kg, started to produce sedation at 30 mg/kg and sedation became strong at 100 mg/kg as rats were almost motionless and none of them were cataleptic.
Chemical Information
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CAS No. 104391-26-6
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Appearance Solid
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Molecular Weight 346.25
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Formula C15H21Cl2N3O2
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Color White to off-white
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SMILES
O=C(NCCN(CC)CC)C1=CC(C#N)=C(Cl)C=C1OC.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 3.5 mg/mL (10.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8881 mL | 14.4404 mL | 28.8809 mL | 72.2022 mL |
| 5 mM | 0.5776 mL | 2.8881 mL | 5.7762 mL | 14.4404 mL | |
| 10 mM | 0.2888 mL | 1.4440 mL | 2.8881 mL | 7.2202 mL |
CGP 25454A Related Classifications
HY-100454 Related Classifications
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