1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. CGP 25454A

CGP 25454A 

Cat. No.: HY-100454 Purity: 99.65%
COA Handling Instructions

CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research.

For research use only. We do not sell to patients.

CGP 25454A Chemical Structure

CGP 25454A Chemical Structure

CAS No. : 104391-26-6

Size Price Stock Quantity
5 mg USD 280 In-stock
10 mg USD 480 In-stock
50 mg USD 960 In-stock
100 mg USD 1650 In-stock
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Description

CGP 25454A is a selective presynaptic dopamine autoreceptor antagonist which induces the increase of dopamine and acetyl choline. CGP 25454A can be used for major depression research[1].

In Vitro

CGP 25454A (0.5-10 μM, 15 min) elicits a reproducible and concentration-dependent increase of the release of both DA and ACh in rat striatal slices with an increase by 62±3% and 100±7% at 10 μM. CGP 25454A is 12.9 fold more potent at pre- than post-synaptic DA receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGP 25454A (10-100 mg/kg, i.p., 60 min) produces a marked, close-dependent increase in Spiperone binding in rat striatum[1].
CGP 25454A (0.5-100 mg/kg, i.p., 10-60 min) exerts opposite effects with a slight behavioral stimulation at low doses and a clear-cut central depressant action in the higher dose range[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Tif rats with Amphetamine-induced hyperactivity[1]
Dosage: 0.5-100 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Did not modify ambulation but increased rearing at 2.5 and 10mg/kg, started to produce sedation at 30 mg/kg and sedation became strong at 100 mg/kg as rats were almost motionless and none of them were cataleptic.
Molecular Weight

346.25

Formula

C15H21Cl2N3O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCN(CC)CC)C1=CC(C#N)=C(Cl)C=C1OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 3.5 mg/mL (10.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8881 mL 14.4404 mL 28.8809 mL
5 mM 0.5776 mL 2.8881 mL 5.7762 mL
10 mM 0.2888 mL 1.4440 mL 2.8881 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.65%

References
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CGP 25454A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CGP 25454A
Cat. No.:
HY-100454
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