1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor

NMI 8739 

Cat. No.: HY-101540
Handling Instructions

NMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine.

For research use only. We do not sell to patients.

NMI 8739 Chemical Structure

NMI 8739 Chemical Structure

CAS No. : 129024-87-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 153 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 520 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

NMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine.

In Vitro

NMI 8739 is a dopamine D2 autoreceptor agonist[1], which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine[2]. NMI 8739 reduces nitric oxide (NO) production in LPS-stimulated RAW264.7 Macrophages. NMI 8739 elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 Release in RAW264.7 macrophages after LPS-stimulation. Production of PGE2 is concentration-dependently suppressed with a reduction of 25.3% at 100 nM NMI 8739 and a 75% reduction for 1 μM NMI 8739. 2 μM NMI 8739 significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectively[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1568 mL 10.7840 mL 21.5680 mL
5 mM 0.4314 mL 2.1568 mL 4.3136 mL
10 mM 0.2157 mL 1.0784 mL 2.1568 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

463.65

Formula

C₃₀H₄₁NO₃

CAS No.

129024-87-9

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NCCC1=CC=C(O)C(O)=C1)=O

Storage

-20°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
NMI 8739
Cat. No.:
HY-101540
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NMI 8739

Cat. No.: HY-101540