country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-145454B

Copy Link Print Information

(Rac)-Preclamol

(Synonyms: (±)-3-PPP)

(Rac)-Preclamol ((±)-3-PPP) is the racemate of (R)-Preclamol (HY-145454A) and Preclamol (HY-145454A). (Rac)-Preclamol exhibits autoreceptor agonistic activity at dopamine Dopamine Receptor, with almost no effect on postsynaptic dopamine receptors. (Rac)-Preclamol inhibits spontaneous motor activity and the γ-butyrolactone-induced increase in mature striatal Tyrosine Hydroxylase activity. (Rac)-Preclamol can be used in research related to neurological diseases.

For research use only. We do not sell to patients.

CAS No.: 75240-91-4
Formula: C₁₄H₂₁NO
Molecular Weight:219.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-Preclamol Chemical Structure

CAS No.: 75240-91-4

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Dopamine Receptor Isoforms :

In Vivo

(Rac)-Preclamol ((±)-3-PPP) (0.1-10 mg/kg; s.c.; single dose; 45 minutes prior to sacrifice (biochemical experiments)) dose-dependently reduces spontaneous locomotor activity and inhibits GBL-induced striatal DOPA accumulation in 28-day-old rats, with no significant effects on locomotion or striatal DOPA accumulation in rats younger than 14 days old^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (ages 1, 4, 7, 14, and 28 days)^[1]
Dosage:

0.1 mg/kg; 1 mg/kg; 10 mg/kg; 10 mg/kg
Administration:

s.c.; single dose; 45 minutes prior to sacrifice
Result:

Reduced 28-day-old rats’ spontaneous locomotor activity in a 0.1-10 mg/kg dose-dependent manner and cut activity to ~30% of control at 10 mg/kg, while exerted no locomotor effects on 1/4/7/14-day-old rats.
Lowered GBL-induced striatal DOPA accumulation from 1618 ng/g to 1127 ng/g in 28-day-old rats at 10 mg/kg and caused only trivial non-significant reduction in 4-day-old rats, without changing striatal and whole-brain DA, NA, DOPAC levels in either age group.

Chemical Information

CAS No. 75240-91-4
Molecular Weight 219.33
Formula C₁₄H₂₁NO
SMILES

OC1=CC=CC(=C1)C2CN(CCC)CCC2
Synonyms

(±)-3-PPP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hedner T, et al. Development of dopamine autoreceptors in the postnatal rat brain. Journal of neural transmission. 1985;62(1-2):53-63. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

(Rac)-Preclamol

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(Rac)-Preclamol Related Classifications

HY-145454B Related Classifications