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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
glucose-lowering effect
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "glucose-lowering effect" in MCE Product Catalog:
Cat. No.: HY-W005629
CAS No.: 1446-61-3
Research Areas:
Leelamine is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor with an IC50 value of 9.5 μM, showing a blood glucose lowering effect in the diabetic mouse. Leelamine is also a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine decreases mitotic activity, prostate-specific antigen expression and induces Apoptosis to cell death in cancer cells .
Cat. No.: HY-N1503
CAS No.: 52613-28-2
Synonyms: 6α-Hydroxygeniposide; Deacetylasperulosidic acid methyl ester
Category:
Iridoids Terpenoids Rubiaceae Metabolic Disease Plants Disease Research Fields Hedyotis diffusa Willd.
Target:
Cat. No.: HY-N3015
CAS No.: 21586-90-3
Category:
Simaroubaceae Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr.
Target:
Cat. No.: HY-148684
CAS No.: 1914176-03-6
Target:
Research Areas:
AMPK activator 10 is an orally active, potent AMPK activator with EC150 of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect .
Cat. No.: HY-146468
CAS No.: 2411099-68-6
Research Areas:
DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC50 of 4.9 μM. DPP-4/GPR119 modulator 1 can be used for diabetes research . DPP-4/GPR119 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-N1503R
CAS No.: 52613-28-2
Synonyms: 6α-Hydroxygeniposide (Standard); Deacetylasperulosidic acid methyl ester (Standard)
Category:
Iridoids Terpenoids Rubiaceae Plants Hedyotis diffusa Willd.
Cat. No.: HY-138842
CAS No.: 118006-14-7
Target:
Research Areas:
DDN is a selective insulin receptor (Insulin Receptor) activator, an insulin sensitizer, and a glucose-lowering insulin mimetic with oral bioavailability. DDN can directly bind to the receptor kinase domain and induce Akt and ERK phosphorylation, and it can also enhance insulin's effect on glucose uptake. DDN significantly reduces blood glucose levels in wild-type and diabetic ob/ob and db/db mice .
Cat. No.: HY-159491
Target:
Research Areas:
DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC50=2.75 μM) with anti-type 2 diabetes activity. DPP-4-IN-11 exerts its glucose-lowering effect by inhibiting the activities of α-glucosidase (IC50=3.02 μM) and α-amylase (IC50=3.3 μM) .
Cat. No.: HY-168329
Research Areas:
TGR5 agonist 7 (Compound 22-Na) is a gut-restricted, orally active agonist for G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 < 1 μM. TGR5 agonist 7 exhibits blood glucose lowering effect in mouse model, and can be used in diabete research .
Cat. No.: HY-19904B
CAS No.: 872260-19-0
Synonyms: (+)-LY2409021
Target:
Research Areas:
(+)-Adomeglivant ((+)-LY2409021) is a potent and selective glycogenotropin receptor antagonist with glucose-lowering activity. (+)-Adomeglivant reduces fasting blood glucose levels in both healthy subjects and patients with type 2 diabetes. The use of (+)-Adomeglivant can help investigate the mechanisms of hyperglycemia in type 2 diabetes. The antagonistic effect of (+)-Adomeglivant makes it challenging to assess the metabolic consequences of postprandial hyperglycemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
