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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
hPR
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "hPR" in MCE Product Catalog:
10
10 Cited Publications
Synonyms: 4-hPR; ISLA-101
Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
Cat. No.: HY-109583
CAS No.: 865536-65-8
Synonyms: 4-Oxo-4-hPR
Research Areas:
4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9 .
Cat. No.: HY-106827
CAS No.: 74513-62-5
Synonyms: RU 27987
Research Areas:
Trimegestone (RU 27987) is an orally active, selective progestogen and PR ligand, with an IC50 of 7.6 nM for hPR, 4.4 nM for rabbit PR, and 3.3 nM for rat PR. Trimegestone induces Alkaline phosphatase activity. Trimegestone exhibits antiandrogenic activity (IC50 = 303 nM). Trimegestone can be used in research related to menopausal symptoms and osteoporosis .
Cat. No.: HY-W442049
CAS No.: 893412-73-2
Synonyms: hPR
Target:
Research Areas:
Hydroxypinacolone retinoate (HPR) is a retinol derivative, which binds directly with retinoic acid receptors (RARs). Hydroxypinacolone retinoate, when used in combination with Retinyl propionate, can be used in anti-skin aging research .
Cat. No.: HY-RS06343
Target:
Research Areas:
HPR Human Pre-designed siRNA Set A contains three designed siRNAs for HPR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-15373R
CAS No.: 65646-68-6
Synonyms: 4-hPR (Standard); ISLA-101 (Standard)
Target:
Research Areas:
Fenretinide (Standard) is the analytical standard of Fenretinide. This product is intended for research and analytical applications. Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
Cat. No.: HY-109583S
CAS No.: 2991099-34-2
Synonyms: 4-Oxo-4-hPR-d4
Cat. No.: HY-167638
CAS No.: 79982-82-4
Synonyms: 4-hPR-O-glucuronide
Target:
Research Areas:
Fenretinide glucuronide (4-HPR-O-glucuronide) is a metabolite formed from Fenretinide (HY-15373) through glucuronidation. The formation of Fenretinide glucuronide enhances the water solubility of Fenretinide and facilitates its excretion. Fenretinide glucuronide holds potential for research in the field of cancer .
Cat. No.: HY-143957S
CAS No.: 2118244-60-1
Synonyms: 4-hPR-O-glucuronide-d4
Cat. No.: HY-119080
CAS No.: 532435-68-0
Target:
Research Areas:
CP8754 is an orally active, selective human progesterone receptor (hPR) antagonist that blocks progesterone-mediated signaling pathways. CP8754 competitively inhibits the binding of [ 3H]-progesterone to hPR. And in vitro, CP8754 inhibits progesterone-dependent exogenous luciferase and endogenous alkaline phosphatase expression; while in vivo, CP8754 inhibits rabbit endometrial transformation. CP8754 does not significantly bind to human glucocorticoid receptors (hGR), estrogen receptors (hER), or rat androgen receptors (rAR). CP8754 can be used in the study of progesterone-related diseases such as breast cancer, endometriosis, uterine fibroids, and meningioma, as well as hormone-dependent tumors .
Cat. No.: HY-183518
CAS No.: 179894-84-9
Research Areas:
LG-120753 is an orally active nonsteroidal progesterone receptor (PR) antagonist, with an IC50 of 38 nM against hPR-B, a Ki of 19 nM against hPR-A, an IC50 of 227 nM against hAR, and IC50 values greater than 1000 nM against hGR, hER and hMR. LG-120753 blocks the action of progesterone, binds to and antagonizes hPR-A, and shows limited cross-reactivity with other steroid receptors. LG-120753 blocks blastocyst implantation, prevents the establishment of pregnancy, exhibits dose-dependent antiprogestogenic activity in vivo, and induces reversible antifertility effects .
Cat. No.: HY-P81692A
Synonyms: Death domain containing protein p84N5; hPR1; hTREX84; Nuclear matrix protein p84; p84N5; THO complex 1; Tho1; Thoc1
Cat. No.: HY-P81479A
Synonyms: THO Complex Subunit 1; Death domain containing protein p84N5; hPR1; hTREX84; Nuclear matrix protein p84; p84N5; THO complex 1; Tho1; Thoc1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
