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Cat. No.: HY-183518

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LG-120753

LG-120753 is an orally active nonsteroidal progesterone receptor (PR) antagonist, with an IC₅₀ of 38 nM against hPR-B, a K_i of 19 nM against hPR-A, an IC₅₀ of 227 nM against hAR, and IC₅₀ values greater than 1000 nM against hGR, hER and hMR. LG-120753 blocks the action of progesterone, binds to and antagonizes hPR-A, and shows limited cross-reactivity with other steroid receptors. LG-120753 blocks blastocyst implantation, prevents the establishment of pregnancy, exhibits dose-dependent antiprogestogenic activity in vivo, and induces reversible antifertility effects.

For research use only. We do not sell to patients.

CAS No.: 179894-84-9
Formula: C₁₉H₁₈N₂
Molecular Weight:274.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LG-120753 Chemical Structure

CAS No.: 179894-84-9

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

In Vivo

LG-120753 (0.1-5.0 mg/mouse; p.o.; daily; 3 days) blocks mouse implantation in a dose-dependent manner, achieving 100% efficacy at 5.0 mg/mouse, and its antifertility effects are fully reversible by co-administration of a steroidal progestin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

unspecified strain (female, virgin)^[1]
Dosage:

0.1 mg/mouse; 0.5 mg/mouse; 1.0 mg/mouse; 2.5 mg/mouse; 5.0 mg/mouse
Administration:

p.o.; daily; 3 days
Result:

Reduced pregnancy rate to 83.3% at 0.1 mg/mouse.
Reduced pregnancy rate to 83.3% at 0.5 mg/mouse.
Reduced pregnancy rate to 66.7% at 1.0 mg/mouse.
Reduced pregnancy rate to 50% at 2.5 mg/mouse.
Reduced pregnancy rate to 0% at 5.0 mg/mouse.
Restored pregnancy rate to 100% when co-administered with steroidal progestin R5020.

Chemical Information

CAS No. 179894-84-9
Molecular Weight 274.36
Formula C₁₉H₁₈N₂
SMILES

N#CC1=CC=CC(C2=CC=C3NC(C)(C)C=C(C)C3=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pooley CL, et al. Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore. Journal of medicinal chemistry. 1998 Aug 27;41(18):3461-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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