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PGRMC1 Antibody (YA3488)(PBS only)

(Synonyms: MPR; HPR6.6)

PGRMC1 Antibody (YA3488) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGRMC1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    IHC-P, ICC/IF, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • PGRMC1 Antibody (YA3488)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:1000 1:200-1:1000 1:200-1:400 1:10000

Product Details

Description

PGRMC1 Antibody (YA3488) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PGRMC1.

  • Host Mouse
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 22 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 22 kDa
Immunogen

Purified recombinant fragment of human PGRMC1 (AA:1-195) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PGRMC1 component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization[1][2][3][4].

  • Subcellular Localization

    Microsome membrane; Single-pass membrane protein; Smooth endoplasmic reticulum membrane; Single-pass membrane protein; Mitochondrion outer membrane; Single-pass membrane protein; Extracellular side; Secreted

  • Expression


    Tissue_specificity:This protein can be detected in urine (protein level) (PubMed:36213313, PubMed:37453717) . It is expressed in the endometrial glands and stroma (protein level) (PubMed:23793472) . This protein is widely expressed, with the highest expression levels in the liver and kidneys.

  • Subunit

    Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions (PubMed:26988023, PubMed:28396637). Interacts with FECH; the interaction results in decreased FECH activity (PubMed:27599036).

  • SwissProt ID

    O00264

  • Gene ID
    10857 [NCBI]
  • Synonyms

    MPR; HPR6.6

PGRMC1 Antibody (YA3488)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • PGRMC1 Antibody (YA3488)(PBS only) Product Image