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PGRMC1 - progesterone receptor membrane component 1 Gene

Also Known as IZA; MPR; Dap1; HPR6.6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10857

About PGRMC1

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:119,236,285-119,244,466 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 180.6), kidney (RPKM 113.3) and 24 other tissues.

Summary

This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

PGRMC1 Products (2)

mRNA	Protein	Name
NM_001282621.2	NP_001269550.1	membrane-associated progesterone receptor component 1 isoform 2
NM_006667.5	NP_006658.1	membrane-associated progesterone receptor component 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables heme binding	IDA IDA: Inferred from direct assay	26988023	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21081644	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	26988023	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in heme biosynthetic process	IDA IDA: Inferred from direct assay	27599036	GOA
involved in positive regulation of lipoprotein transport	IMP IMP: Inferred from mutant phenotype	30443021	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	25390692	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGRMC1 Protein Structure

Cyt-b5

0
100
195 a.a.

Protein Preferred Names	Protein Names
membrane-associated progesterone receptor component 1	progesterone binding protein

PGRMC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PGRMC1	O00264	PGRMC2	Homo sapiens	O15173	Anti Tag CoIP	35271311
Intra	PGRMC1	O00264	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	PGRMC2	Homo sapiens	O15173	Validated Y2H	32296183
Intra	PGRMC1	O00264	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	PGRMC1	O00264	KCNE5	Homo sapiens	Q9UJ90	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	KCNE5	Homo sapiens	Q9UJ90	Validated Y2H	32296183
Intra	PGRMC1	O00264	KCNE5	Homo sapiens	Q9UJ90	Y2H Array	32296183
Intra	PGRMC1	O00264	DEFB124	Homo sapiens	Q8NES8	Validated Y2H	32296183
Intra	PGRMC1	O00264	DEFB124	Homo sapiens	Q8NES8	Y2H Array	32296183
Intra	PGRMC1	O00264	DEFB124	Homo sapiens	Q8NES8	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	CAMLG	Homo sapiens	P49069	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	CAMLG	Homo sapiens	P49069	Validated Y2H	32296183
Intra	PGRMC1	O00264	CAMLG	Homo sapiens	P49069	Y2H Array	32296183
Intra	PGRMC1	O00264	EVI2B	Homo sapiens	P34910-2	Validated Y2H	32296183
Intra	PGRMC1	O00264	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	PGRMC1	O00264	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	GET3	Homo sapiens	O43681	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	GET3	Homo sapiens	O43681	Validated Y2H	32296183
Intra	PGRMC1	O00264	GET3	Homo sapiens	O43681	Y2H Array	32296183
Intra	PGRMC1	O00264	DHCR24	Homo sapiens	Q15392	Anti Tag CoIP	35271311
Intra	PGRMC1	O00264	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	PGRMC1	O00264	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	PGRMC1	O00264	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
Intra	PGRMC1	O00264	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	PGRMC1	O00264	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	ZNF71	Homo sapiens	Q9NQZ8	Y2H Array	32296183
Intra	PGRMC1	O00264	ZNF71	Homo sapiens	Q9NQZ8	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	ZNF71	Homo sapiens	Q9NQZ8	Validated Y2H	32296183
Intra	PGRMC1	O00264	CIAO1	Homo sapiens	O76071	Validated Y2H	32296183
Intra	PGRMC1	O00264	CIAO1	Homo sapiens	O76071	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	CIAO1	Homo sapiens	O76071	Y2H Array	32296183
Intra	PGRMC1	O00264	POR	Homo sapiens	P16435	Anti Tag CoIP	21081644
Intra	PGRMC1	O00264	POR	Homo sapiens	P16435	Anti Tag CoIP	35271311
Intra	PGRMC1	O00264	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	PGRMC1	O00264	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	PGRMC1	O00264	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	PGRMC1	O00264	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	PGRMC1	O00264	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	PGRMC1	O00264	CCDC134	Homo sapiens	Q9H6E4	Validated Y2H	32296183
Intra	PGRMC1	O00264	CCDC134	Homo sapiens	Q9H6E4	Y2H Array	32296183
Intra	PGRMC1	O00264	CCDC134	Homo sapiens	Q9H6E4	Y2H Prey Pooling	32296183
Cross	PGRMC1	O00264	CYP2C2	Oryctolagus cuniculus	P00181	Confocal	21081644
Cross	PGRMC1	O00264	CYP2C2	Oryctolagus cuniculus	P00181	Anti Tag CoIP	21081644

Cross: Cross-species interaction Intra: Intraspecies interaction

PGRMC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83791	PGRMC1 Antibody (YA3488)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P83791A	PGRMC1 Antibody (YA3488)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Cataract 44	CTRCT44 Total Early-Onset Cataract Cataract 44 And Hypotrichosis Cataract And Hypotrichosis Cataract, Type 44
Extragonadal Germ Cell Cancer	Extragonadal Germ Cell Tumor Extragonadal Germ Cell Malignant Tumor Neoplasm Of Extragonadal Germ Cell Tumor Of Extragonadal Germ Cell
Preterm Premature Rupture Of The Membranes	Preterm Premature Rupture Of Membranes PPROM Preterm Premature Rupture Of The Membranes, Susceptibility To Pprom - [Preterm Premature Rupture Of Membranes] Preterm Rupture Of Membranes
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Niemann-Pick Disease, Type C1	Niemann-Pick Disease, Type C NPC1 Niemann-Pick Disease, Type D Niemann-Pick Disease Type C1 Niemann-Pick Disease With Cholesterol Esterification Block Niemann-Pick Disease, Subacute Juvenile Form Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia Npc Niemann-Pick Disease, Chronic Neuronopathic Form Niemann-Pick Disease Without Sphingomyelinase Deficiency Niemann-Pick Disease Type C Niemann-Pick Disease Type D Niemann-Pick C1 Disease Niemann-Pick Disease C1 Niemann-Pick Disease Chronic Neuronopathic Form Niemann-Pick Disease Nova Scotian Type Niemann-Pick Disease Subacute Juvenile Form Niemann-Pick Disease Type Ii Niemann-Picks Disease Type C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115625	AG-205		99%	Unkown
HY-116968	JVW-1009	Antagonist	/	Unkown
HY-119386	SAS-0132		/	Unkown
HY-120008	SAS-1121	Ligand	/	Unkown
HY-121012	(rac)-AG-205		/	Unkown
HY-RS10399	PGRMC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20577	Pgrmc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27085	Pgrmc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PGRMC1	VGNC	VGNC:75806
Canis familiaris	PGRMC1	VGNC	VGNC:44470
Mus musculus	PGRMC1	MGD	MGI:1858305
Rattus norvegicus	PGRMC1	RGD	RGD:70890
Bos taurus	PGRMC1	VGNC	VGNC:32801
Others	PGRMC1	NCBI