human APC

By Targets:	APC (6) Apoptosis (2) Biochemical Assay Reagents (2) Complement System (1) Emopamil Binding Protein (1) Factor XI (2) Ferroptosis (1) PARP (1) PKG (1) Ser/Thr Protease (2) Small Interfering RNA (siRNA) (3) VISTA (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Inflammation/Immunology (4)
Oligonucleotides:	Human Pre-designed siRNA Sets (3) siRNAs (3)

Targets Recommended: APC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117930

Danicopan 4 Publications Verification ACH-4471	Complement System	Inflammation/Immunology
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with K_d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

HY-164561

TASIN-30 1 Publications Verification	Emopamil Binding Protein Ferroptosis Apoptosis	Cancer
TASIN-30 is a selective EBP inhibitor with an EC₅₀ of 0.097 μM. TASIN-30 blocks the production of 7-dehydrocholesterol (7-DHC) and downstream cholesterol biosynthesis processes. TASIN-30 depletes downstream sterols, disrupts the integrity of lipid rafts in tumor cells, accelerates intracellular cholesterol consumption, and inhibits tumor cell proliferation. TASIN-30 induces ferroptosis and apoptosis by reducing 7-DHC levels and increasing phospholipid peroxidation. TASIN-30 achieves tumor suppression in nude mice with osteosarcoma. TASIN-30 can be used in cancer-related research such as colorectal cancer and osteosarcoma .

HY-137849

RK-582	PARP	Cancer
RK-582 is a tankyrase inhibitor, antitumor agent, and orally bioavailable growth inhibitor, with an IC₅₀ of 36.1 nM against human tankyrase-1 and an IC₅₀ of 39.2 nM against human tankyrase-2. In APC-mutated colorectal cancer cells, the sensitivity to RK-582 correlates with the level of active β-catenin, while drug resistance associates with PIK3CA mutation. RK-582 can be used for the research of colorectal cancer .

HY-P1918

Activated Protein C (390-404), human 4 Publications Verification	APC	Cardiovascular Disease
Activated Protein C (390-404), human is a polypeptide fragment of vitamin K-dependent serine protease activated protein C (APC), which inhibits the anticoagulant activity of *APC. Activated Protein C (390-404), human* inhibits APC-catalyzed inactivation of factor Va .

HY-122142A

Pyr-Pro-Arg-pNA (hydrochloride) S-2366 (hydrochloride)	APC Factor XI Biochemical Assay Reagents	Others
Pyr-Pro-Arg-pNA (S-2366) hydrochloride is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-Pro-Arg-pNA hydrochloride functions as a hydrolyzable substrate for FXIa’s catalytic domain, human *APC, murine APC*, and purified plasma kallikrein .

HY-112968

Human protein C	APC	Cardiovascular Disease
Human Protein C is activated by α-thrombin or α-thrombin/thrombomodulin complex to a serine protease, namely activated protein C (APC). Human Protein C can selectively inactivate factors Va and VIIIa and is a potent anticoagulant .

HY-103255

CFM-4	Apoptosis	Cancer
CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G₂M cell cycle arrest, and induces apoptosis with an IC₅₀ range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells .

HY-122142

Pyr-Pro-Arg-pNA S-2366	Biochemical Assay Reagents APC Factor XI	Inflammation/Immunology
Pyr-Pro-Arg-pNA (S-2366) is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-Pro-Arg-pNA functions as a hydrolyzable substrate for FXIa’s catalytic domain, human *APC, murine APC*, and purified plasma kallikrein .

HY-RS00807

APC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APC Human Pre-designed siRNA Set A contains three designed siRNAs for APC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APC Human Pre-designed siRNA Set A APC Human Pre-designed siRNA Set A

HY-RS00810

APC2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APC2 Human Pre-designed siRNA Set A contains three designed siRNAs for APC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APC2 Human Pre-designed siRNA Set A APC2 Human Pre-designed siRNA Set A

HY-114015

APC-6860	Ser/Thr Protease	Cancer
APC-6860 is a trypsin-like serine proteases inhibitor with k_i values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k_i values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer .

HY-105999A

APC 366 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
APC 366 hydrochloride is a selective inhibitor of mast cell trypsin activity. APC 366 hydrochloride is able to inhibit trypsin-induced histamine release in human tonsil and lung cells. APC 366 hydrochloride may have important applications in regulating allergic reactions and inflammation .

HY-153542

AP-C6	PKG	Others
AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition .

HY-116473

CFM-1	APC	Cancer
CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC₅₀ value of 4.1 μM. CFM-1 induces G₂M cell cycle arrest and suppresses viabilities of human breast cancer cells .

HY-P1918A

*Activated Protein C (390-404), human* TFA**	APC	Cardiovascular Disease
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-RS16390

*APCS Human* Pre-designed siRNA Set A**	Small Interfering RNA (siRNA)	Others
APCS Human Pre-designed siRNA Set A contains three designed siRNAs for APCS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APCS Human Pre-designed siRNA Set A APCS Human Pre-designed siRNA Set A

HY-P991765

Anti-VISTA Antibody (GG8)	VISTA	Inflammation/Immunology
Anti-VISTA Antibody (GG8) reacts with human VISTA. Endogenous VISTA has inhibitory effects both as a ligand on APCs and as a receptor on T cells. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

Cat. No.	Product Name	Target	Research Area

HY-P1918

Activated Protein C (390-404), human 4 Publications Verification	APC	Cardiovascular Disease
Activated Protein C (390-404), human is a polypeptide fragment of vitamin K-dependent serine protease activated protein C (APC), which inhibits the anticoagulant activity of *APC. Activated Protein C (390-404), human* inhibits APC-catalyzed inactivation of factor Va .

HY-P1918A

*Activated Protein C (390-404), human* TFA**	APC	Cardiovascular Disease
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991765

Anti-VISTA Antibody (GG8)	VISTA	Inflammation/Immunology
Anti-VISTA Antibody (GG8) reacts with human VISTA. Endogenous VISTA has inhibitory effects both as a ligand on APCs and as a receptor on T cells. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .

Species:	Human (7)
Tag:	His (5) Tag Free (1) Avi (3) Fc (1)
Source:	HEK293 (6) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701853

	APC Protein, Human (His) APC; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5	Human	E. coli
	The APC protein is a multifaceted tumor suppressor that rapidly degrades CTNNB1 and acts as a negative regulator in the Wnt pathway. Its phosphorylation status intricately affects activity. APC Protein, Human (His) is the recombinant human-derived APC protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74237

	*Coagulation Factor XIV/PROC Protein, Human* (HEK293, His)** Vitamin K-dependent protein C; APC; Protein C; PROC	Human	HEK293
	Coagulation Factor XIV/PROC is a vital vitamin K-dependent serine protease regulating blood coagulation. Active Protein C inactivates factors Va and VIIIa in the presence of calcium ions and phospholipids, maintaining the intricate balance of coagulation pathways. Its protective effect on endothelial cell barrier function underscores a broader impact on vascular integrity. Coagulation Factor XIV/PROC Protein, Human (HEK293, His) is the recombinant human-derived Coagulation Factor XIV/PROC protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor XIV/PROC Protein, Human (HEK293, His) is 443 a.a., with molecular weight of 56-64 & 45 kDa, respectively.

HY-P70936

	*EPCR Protein, Human* (HEK293, His)** Endothelial Protein C Receptor; Activated Protein C Receptor; APC Receptor; Endothelial Cell Protein C Receptor; CD201; PROCR; EPCR	Human	HEK293
	EPCR Protein binds activated protein C, enhancing its activation by the thrombin-thrombomodulin complex, and is pivotal in the protein C pathway, regulating blood coagulation. EPCR Protein, Human (HEK293, His) is the recombinant human-derived EPCR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P705104

	*TNF-alpha/TNFSF2 Protein, Human* (Biotinylated, HEK293)** APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2	Human	HEK293

HY-P78527

	*TNF-alpha/TNFSF2 Protein, Human* (HEK293, His-Avi)** APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2	Human	HEK293
	Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine. TNF alpha binds to its receptors, mainly TNFR1 and TNFR2, and then transmits molecular signals for biological functions such as inflammation and cell death. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis. Anti-TNF-α MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse. TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury. TNF-alpha/TNFSF2 Protein, Human (HEK293, His-Avi) is a recombinant protein with a C-Terminal Avi and a His label, It consists of 157 amino acids (V77-L233) and is produced in HEK293 cells.

HY-P78218

	*TNF-alpha/TNFSF2 Protein, Human* (Biotinylated, HEK293, His-Avi)** 2 Publications Verification APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2	Human	HEK293
	Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine. TNF alpha binds to its receptors, mainly TNFR1 and TNFR2, and then transmits molecular signals for biological functions such as inflammation and cell death. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis. Anti-TNF-α MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse. TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury. TNF-alpha/TNFSF2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant protein with C-Terminal Avi and His label, It consists of 157 amino acids (V77-L233) and is produced in HEK293 cells.

HY-P705103

	*TNF-alpha/TNFSF2 Protein, Human* (Biotinylated, HEK293, Fc-Avi)** APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2	Human	HEK293

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Host:	Mouse (2) Rabbit (1) Goat (1)
Reactivity:	Human (4)
Application:	IHC-P (1) ICC/IF (3) IF-Tissue (1) WB (1) FC (4) ELISA (1)
Isotype:	IgG (2) IgG2b (1)
Conjugation:	APC (3) Non-conjugated (1) Biotin (3)
Clonality:	Polyclonal (2) Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P89234

	APC-conjugated Goat Anti-Human IgG H&L	IHC-P, ICC/IF, FC, ELISA	Human
	APC-conjugated Goat Anti-Human IgG H&L is an APC-conjugated, Goat-derived anti-Human antibody. APC-conjugated Goat Anti-Human IgG H&L conjugates the light and heavy chains of mouse IgG antibodies.

HY-P89358

	APC-conjugated Mouse Anti-Human IgG H&L	ICC/IF, IF-Tissue, FC	Human
	APC-conjugated Mouse Anti-Human IgG H&L is an APC-conjugated, Mouse-derived anti-HumanIgG antibody. APC-conjugated Mouse Anti-Human IgG H&L conjugates the light and heavy chains of mouse IgG antibodies.

HY-P83666M

	Human CD235 Antibody (APC) (YA3400) Glycophorin-A/B; GYPA/B; MN sialoglycoprotein; SS-active sialoglycoprotein; PAS-2/3; Sialoglycoprotein alpha/delta; CD235a/b	FC	Human
	Human CD235 Antibody (APC) (YA3400) is an APC-conjugated, mouse-derived, anti-Human CD235 IgG1 monoclonal antibody.

HY-P86862

	EPCR Antibody (YA6555) Activated protein C receptor antibody; APC receptor antibody; APCR antibody; bA42O4.2 antibody; CCCA antibody; CCD41 antibody; CD201 antibody; CD201 antigen antibody; cell cycle, centrosome-associated protein antibody; Cell cycle, centrosome-associated protein antibody; Activated protein C receptor antibody; APC receptor antibody; APCR antibody; bA42O4.2 antibody; CCCA antibody; CCD41 antibody; CD201 antibody; CD201 antigen antibody; cell cycle, centrosome-associated protein antibody; Cell cycle, centrosome-associated protein antibody; centrocyclin antibody; Endothelial cell protein C receptor antibody; Endothelial protein C receptor antibody; EPCR antibody; EPCR_human antibody; MGC23024 antibody; PROCR antibody; Protein C receptor, endothelial antibody;	WB, ICC/IF, FC	Human
	EPCR Antibody (YA6555) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EPCR.

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Cat. No.	Product Name		Classification

HY-RS00807

APC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
APC Human Pre-designed siRNA Set A contains three designed siRNAs for APC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00810

APC2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
APC2 Human Pre-designed siRNA Set A contains three designed siRNAs for APC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16390

*APCS Human* Pre-designed siRNA Set A**		siRNAs Human Pre-designed siRNA Sets
APCS Human Pre-designed siRNA Set A contains three designed siRNAs for APCS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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