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hydrangea

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By Targets:	Cholinesterase (ChE) (1) COX (1) Environmental Pollutants (1) ERK (1) GLUT (1) Interleukin Related (2) Keap1-Nrf2 (1) MMP (1) p38 MAPK (1) Parasite (1) Phosphodiesterase (PDE) (1) PPAR (1) Reference Standards (1) TGF-β Receptor (1) TNF Receptor (2)
By Research Areas:	Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2263

Skimmin 1 Publications Verification Umbelliferone glucoside	Interleukin Related TGF-β Receptor TNF Receptor Parasite	Inflammation/Immunology
Skimmin (Umbelliferone glucoside) is a major pharmacologically active and orally active molecule present in Hydrangea paniculata, a medical herb used in traditional Chinese medicine as an anti-inflammatory agent. Skimmin has renal protective activity. Skimmin can improve creatinine clearance, and reduce plasma creatinine, and kidney injuries. Skimmin has good anti-amoebic activity against the HM1:IMMS strain of Entamoeba histolytica. Skimmin has anti-cancer and neuroprotective activities. Skimmin reduces cardiac fibrosis as well as decreasing TNF-α, IL-6, IL1β, and TGFβ1 in cardiac tissues. Skimmin can be studied in research for diabetes and diabetes-related diseases .

HY-N4028

Hydrangenol	MMP COX Interleukin Related p38 MAPK ERK Keap1-Nrf2	Inflammation/Immunology
Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level .

HY-W044525

Phyllodulcin	Phosphodiesterase (PDE)	Metabolic Disease Inflammation/Immunology
Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii. Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling .

HY-W010409

2-Octanone n-Hexyl methyl ketone	Environmental Pollutants	Others
2-Octanone (n-Hexyl methyl ketone) is a Flavonoids product that can be isolated from the herbs of Hydrangea macrophylla .

HY-N4027

Hydrangenol 8-O-glucoside Hydrangenol 8-O-β-D-glucopyranoside	Cholinesterase (ChE)	Neurological Disease
Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an AChE inhibitor (IC₅₀: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction .

HY-N8224A

(E)-5-O-Cinnamoylquinic acid	Others	Others
(E)-5-O-Cinnamoylquinic acid is the isomer of 5-O-Cinnamoylquinic acid. 5-O-Cinnamoylquinic acid is a co-pigment. 5-O-Cinnamoylquinic acid could form the stable blue solution to clarify the mechanism of blue sepal-color development of hydrangea .

HY-N8868

Hemiphroside B nonaacetate	Others	Others
Hemiphroside B nonaacetate is a Phenols product that can be isolated from the herbs of Hydrangea macrophylla .

HY-N0962A

(3S)-Hydrangenol 8-O-glucoside pentaacetate	Others	Others
(3S)-Hydrangenol 8-O-glucoside pentaacetate is a Flavonoids product that can be isolated from the herbs of Hydrangea macrophylla .

HY-N0962

(3R)-Hydrangenol 8-O-glucoside pentaacetate	Others	Others
(3R)-Hydrangenol 8-O-glucoside pentaacetate is a Flavonoids product that can be isolated from the herbs of Hydrangea macrophylla .

HY-W010409R

2-Octanone (Standard) n-Hexyl methyl ketone (Standard)	Others Reference Standards	Others
2-Octanone (n-Hexyl methyl ketone) (Standard) is the analytical standard of 2-Octanone (HY-W010409). This product is intended for research and analytical applications. 2-Octanone is a Flavonoids product that can be isolated from the herbs of Hydrangea macrophylla .

HY-N17773

Hydrangeic acid	PPAR GLUT TNF Receptor	Metabolic Disease
Hydrangeic acid is an orally effective stilbene-type glycolipid metabolism regulator that lowers blood glucose and lipids. It can be isolated from processed leaves of Hydrangea macrophylla var. thunbergii. Hydrangeic acid is associated with glycolipid metabolism and insulin sensitivity regulation. Hydrangeic acid does not directly activate PPARγ or PPARα, but instead upregulates the mRNA expression of adiponectin, PPARγ2, GLUT4, and fatty acid-binding protein aP2, and downregulates TNF-α mRNA expression, promoting adipogenesis, glucose uptake, and GLUT4 translocation in 3T3-L1 cells. Simultaneously, Hydrangeic acid inhibits inflammatory factor-induced NO production, exerting activity in improving insulin resistance. Hydrangeic acid can be used in research related to type 2 diabetes and does not cause liver weight gain as a side effect.

Skimmin 1 Publications Verification Umbelliferone glucoside	Classification of Application Fields Polygalaceae Polygala japonica Houtt. Coumarins Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Interleukin Related TGF-β Receptor TNF Receptor Parasite
Skimmin (Umbelliferone glucoside) is a major pharmacologically active and orally active molecule present in Hydrangea paniculata, a medical herb used in traditional Chinese medicine as an anti-inflammatory agent. Skimmin has renal protective activity. Skimmin can improve creatinine clearance, and reduce plasma creatinine, and kidney injuries. Skimmin has good anti-amoebic activity against the HM1:IMMS strain of Entamoeba histolytica. Skimmin has anti-cancer and neuroprotective activities. Skimmin reduces cardiac fibrosis as well as decreasing TNF-α, IL-6, IL1β, and TGFβ1 in cardiac tissues. Skimmin can be studied in research for diabetes and diabetes-related diseases .

Hydrangenol	Classification of Application Fields Anti-aging Hydrangeaceae Coumarins Phenylpropanoids Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Source Classification	MMP COX Interleukin Related p38 MAPK ERK Keap1-Nrf2
Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level .

2-Octanone n-Hexyl methyl ketone	Structural Classification Natural Products Animals Source Classification	Environmental Pollutants
2-Octanone (n-Hexyl methyl ketone) is a Flavonoids product that can be isolated from the herbs of Hydrangea macrophylla .

Hydrangenol 8-O-glucoside Hydrangenol 8-O-β-D-glucopyranoside	Hydrangeaceae Coumarins Phenylpropanoids Plants Source Classification	Cholinesterase (ChE)
Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an AChE inhibitor (IC₅₀: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction .

(E)-5-O-Cinnamoylquinic acid	Animals Ketones, Aldehydes, Acids Phenylpropanoids Source Classification	Others
(E)-5-O-Cinnamoylquinic acid is the isomer of 5-O-Cinnamoylquinic acid. 5-O-Cinnamoylquinic acid is a co-pigment. 5-O-Cinnamoylquinic acid could form the stable blue solution to clarify the mechanism of blue sepal-color development of hydrangea .

Hemiphroside B nonaacetate	Xanthones Hydrangeaceae Phenols Plants Source Classification	Others
Hemiphroside B nonaacetate is a Phenols product that can be isolated from the herbs of Hydrangea macrophylla .

(3S)-Hydrangenol 8-O-glucoside pentaacetate	Flavonoids Hydrangeaceae Plants Other Flavonoids Source Classification	Others
(3S)-Hydrangenol 8-O-glucoside pentaacetate is a Flavonoids product that can be isolated from the herbs of Hydrangea macrophylla .

(3R)-Hydrangenol 8-O-glucoside pentaacetate	Flavonoids Hydrangeaceae Plants Other Flavonoids Source Classification	Others
(3R)-Hydrangenol 8-O-glucoside pentaacetate is a Flavonoids product that can be isolated from the herbs of Hydrangea macrophylla .

2-Octanone (Standard) n-Hexyl methyl ketone (Standard)	Structural Classification Natural Products Animals Source Classification	Others Reference Standards
2-Octanone (n-Hexyl methyl ketone) (Standard) is the analytical standard of 2-Octanone (HY-W010409). This product is intended for research and analytical applications. 2-Octanone is a Flavonoids product that can be isolated from the herbs of Hydrangea macrophylla .

Hydrangeic acid	Structural Classification Monophenols Hydrangeaceae Phenols Plants Source Classification	PPAR GLUT TNF Receptor
Hydrangeic acid is an orally effective stilbene-type glycolipid metabolism regulator that lowers blood glucose and lipids. It can be isolated from processed leaves of Hydrangea macrophylla var. thunbergii. Hydrangeic acid is associated with glycolipid metabolism and insulin sensitivity regulation. Hydrangeic acid does not directly activate PPARγ or PPARα, but instead upregulates the mRNA expression of adiponectin, PPARγ2, GLUT4, and fatty acid-binding protein aP2, and downregulates TNF-α mRNA expression, promoting adipogenesis, glucose uptake, and GLUT4 translocation in 3T3-L1 cells. Simultaneously, Hydrangeic acid inhibits inflammatory factor-induced NO production, exerting activity in improving insulin resistance. Hydrangeic acid can be used in research related to type 2 diabetes and does not cause liver weight gain as a side effect.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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hydrangea

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