21499-23-0
21499-23-0
Chemical Structure
Phyllodulcin
- CAS No.: 21499-23-0
- Formula:C16H14O5
- Molecular Weight:286.28
IUPAC Name: (+)-PHYLLODULCIN
InChIKey: PBILBHLAPJTJOT-CQSZACIVSA-N
SMILES: COC1=C(C=C(C=C1)[C@H]2CC3=C(C(=CC=C3)O)C(=O)O2)O
Biological Activity: Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii. Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling[1][2].
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Phyllodulcin | 99.75% | Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii. Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.84
HY-N19703(+)-Hydrangenol monomethyl ether -
Similarity Score 0.81
HY-N4028Hydrangenol -
Similarity Score 0.77
HY-N1151Thunberginol C -
Similarity Score 0.67
HY-N2830Agrimonolide -
Similarity Score 0.63
HY-N191033-(2-Hydroxypropyl)-8-hydroxy-3,4-dihydroisocoumarin -
Similarity Score 0.62
HY-N7626Eleutherol -
Similarity Score 0.61
HY-N16401Aspergillumarin B -
Similarity Score 0.61
HY-103431RA68930 hydrochloride (Standard) -
Similarity Score 0.61
HY-N101645,6-Desmethylenedioxy-5-methoxyaglalactone -
Explore the MedChemAI to find more analogs
References
- [1]. Liu J, et al. Medicinal flowers. XXXX . Structures of dihydroisocoumarin glycosides and inhibitory effects on aldose reducatase from the flowers of Hydrangea macrophylla var.thunbergii. Chem Pharm Bull (Tokyo). 2013;61(6):655-61. [Content Brief]
- [2]. Kim E, et al. Phyllodulcin, a Natural Sweetener, Regulates Obesity-Related Metabolic Changes and Fat Browning-Related Genes of Subcutaneous White Adipose Tissue in High-Fat Diet-Induced Obese Mice. Nutrients. 2017 Sep 21;9(10):1049. [Content Brief]
