480-47-7
480-47-7
Chemical Structure
Hydrangenol
- No. CAS: 480-47-7
- Formula:C15H12O4
- Molecular Weight:256.25
IUPAC Name: 8-hydroxy-3-(4-hydroxyphenyl)isochroman-1-one
InChIKey: DGKDFNDHPXVXHW-UHFFFAOYSA-N
SMILES: O=C1C2=C(O)C=CC=C2CC(C3=CC=C(O)C=C3)O1
Biological Activity: Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Hydrangenol | 99.62% | Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing MMP and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level. | ||||||||||||||||||||
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A68930 | A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis. | |||||||||||||||||||||
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Lunularic acid | 99.45% | Lunularic acid is a dihydrostilbene compound with anti-hyaluronidase activity (IC50: 0.13 nM). Lunularic acid can be used as an endogenous growth inhibitor in liverworts, replacing the function of abscisic acid in higher plants. | ||||||||||||||||||||
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Thunberginol C | Thunberginol C is an orally active, selective, and non-competitive inhibitor of AChE and BChE, with IC50 values of 41.96 and 42.36 μM, respectively. Thunberginol C exerts cytoprotective, pro-collagen type I restorative, MMP-1 inhibitory, hyaluronic acid restorative, anti-photoaging effects in skin cells. Thunberginol C exerts neuroprotective, anxiolytic, TNF-α inhibitory, neuroinflammation inhibitory, and oxidative stress inhibitory effects. Thunberginol C can be used for the research of Alzheimer’s disease, UVB-induced skin photoaging, allergic reactions, oral bacterial infections, and stress-induced anxiety. | |||||||||||||||||||||
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Aspergillumarin A | Aspergillumarin A is a dihydroisocoumarin derivative with various biological activity. Aspergillumarin A inhibits cell proliferation by inducing G0/G1 phase arrest in HepG2 hepatocellular carcinoma cells.. Aspergillumarin A exhibits weak antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Aspergillumarin A can be used for the study of hepatocellular carcinoma (HCC) | |||||||||||||||||||||
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Aspergillumarin B | Aspergillumarin B (Compound 2) is a derivative of dihydroisocoumarin. Aspergillumarin B can be isolated from the endophytic fungus Aspergillus sp.. Aspergillumarin B has a weak antibacterial activity against Staphylococcus aureus and Bacillus subtilis. | |||||||||||||||||||||
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Hydrangeic acid | Hydrangeic acid is an orally effective stilbene-type glycolipid metabolism regulator that lowers blood glucose and lipids. It can be isolated from processed leaves of Hydrangea macrophylla var. thunbergii. Hydrangeic acid is associated with glycolipid metabolism and insulin sensitivity regulation. Hydrangeic acid does not directly activate PPARγ or PPARα, but instead upregulates the mRNA expression of adiponectin, PPARγ2, GLUT4, and fatty acid-binding protein aP2, and downregulates TNF-α mRNA expression, promoting adipogenesis, glucose uptake, and GLUT4 translocation in 3T3-L1 cells. Simultaneously, Hydrangeic acid inhibits inflammatory factor-induced NO production, exerting activity in improving insulin resistance. Hydrangeic acid can be used in research related to type 2 diabetes and does not cause liver weight gain as a side effect. | |||||||||||||||||||||
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3-(2-Hydroxypropyl)-8-hydroxy-3,4-dihydroisocoumarin | 3-(2-Hydroxypropyl)-8-hydroxy-3,4-dihydroisocoumarin is a 3,4-dihydroisocoumarin derivative found in some fungi and Catunaregam spinosa. 3-(2-Hydroxypropyl)-8-hydroxy-3,4-dihydroisocoumarin exhibits no significant monoamine oxidase or PI3Kα inhibitory activity. | |||||||||||||||||||||
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(+)-Hydrangenol monomethyl ether | (+)-Hydrangenol monomethyl ether is a hydrangenol-monomethyl ether (+)-enantiomer found in axenic cultures of the liverwort Plagiochila adianthoides. | |||||||||||||||||||||
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Agrimonolide | 98% | Agrimonolide is a phenethyl isocoumarin compound discovered from Agrimonia pilosa, exhibiting anti-inflammatory, antioxidant, and anticancer activities. Agrimonolide inhibits NF-κB, MAPK, and TLR4-mediated neuroinflammatory signaling, suppresses Notch and JAK2/STAT3 signaling to modulate Th17/Treg balance and maintain the intestinal barrier. Agrimonolide decreases HIF1A expression, inhibits glycolysis, and induces ferroptosis and cell cycle arrest via the mTOR pathway in tumor models, thereby suppressing cancer cell viability, proliferation, and metastasis. Agrimonolide exerts hepatoprotective and anti-fibrotic effects by regulating bile acid transporter expression and reducing hepatic bile acid accumulation. Agrimonolide is used for research on ulcerative colitis, ovarian cancer, non-small cell lung cancer, cholestatic liver injury, and neuroinflammation. | ||||||||||||||||||||
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Phyllodulcin | 99.75% | Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii. Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling. | ||||||||||||||||||||
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