93-39-0
Chemical Structure
Skimmin
Synonym(s): Umbelliferone glucoside
- CAS No.: 93-39-0
- Formula:C15H16O8
- Molecular Weight:324.28
IUPAC Name: 7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one
InChIKey: VPAOSFFTKWUGAD-TVKJYDDYSA-N
SMILES: O=C1C=CC2=CC=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C=C2O1
Biological Activity: Skimmin (Umbelliferone glucoside) is a major pharmacologically active and orally active molecule present in Hydrangea paniculata, a medical herb used in traditional Chinese medicine as an anti-inflammatory agent. Skimmin has renal protective activity. Skimmin can improve creatinine clearance, and reduce plasma creatinine, and kidney injuries. Skimmin has good anti-amoebic activity against the HM1:IMMS strain of Entamoeba histolytica. Skimmin has anti-cancer and neuroprotective activities. Skimmin reduces cardiac fibrosis as well as decreasing TNF-α, IL-6, IL1β, and TGFβ1 in cardiac tissues. Skimmin can be studied in research for diabetes and diabetes-related diseases[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Skimmin | 99.64% | Skimmin (Umbelliferone glucoside) is a major pharmacologically active and orally active molecule present in Hydrangea paniculata, a medical herb used in traditional Chinese medicine as an anti-inflammatory agent. Skimmin has renal protective activity. Skimmin can improve creatinine clearance, and reduce plasma creatinine, and kidney injuries. Skimmin has good anti-amoebic activity against the HM1:IMMS strain of Entamoeba histolytica. Skimmin has anti-cancer and neuroprotective activities. Skimmin reduces cardiac fibrosis as well as decreasing TNF-α, IL-6, IL1β, and TGFβ1 in cardiac tissues. Skimmin can be studied in research for diabetes and diabetes-related diseases. | ||||||||||||||||||||
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References
- [1]. Zhang S, et al. Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition. Evid Based Complement Alternat Med. 2013;2013:819296. [Content Brief]
- [2]. Lou, Y., et al., (2020). Determination and pharmacokinetic study of skimmin by UHPLC-MS/MS in rat plasma. Journal of pharmaceutical and biomedical analysis, 179, 112969. [Content Brief]
- [3]. Liang, R. K., et al., (2021). Skimmin protects diabetic cardiomyopathy in streptozotocin-induced diabetic rats. The Kaohsiung journal of medical sciences, 37(2), 136–144. [Content Brief]
- [4]. Zhang, S., et al., (2012). Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats. European journal of pharmacology, 692(1-3), 78–83. [Content Brief]
