7-Hydroxycoumarin glucuronide

Cat. No.: HY-N9440: Data Sheet
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Handling Instructions
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7-Hydroxycoumarin glucuronide is a transport substrate and main human coumarin metabolite.7-Hydroxycoumarin glucuronide undergoes ATP-dependent efflux transport via MRP3 and MRP4.7-Hydroxycoumarin glucuronide undergoes active transport processes for urinary excretion and is primarily excreted into urine in humans.

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7-Hydroxycoumarin glucuronide Chemical Structure

CAS No. : 66695-14-5

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

7-Hydroxycoumarin glucuronide is a transport substrate and main human coumarin metabolite.^[1]7-Hydroxycoumarin glucuronide undergoes ATP-dependent efflux transport via MRP3 and MRP4.^[1]7-Hydroxycoumarin glucuronide undergoes active transport processes for urinary excretion and is primarily excreted into urine in humans.^[1]

In Vitro

7-Hydroxycoumarin glucuronide (400 μM; 10-20 min) is a substrate of MRP3 (K_m = 187 μM) and MRP4 (K_m = 63 μM) efflux transporters, but not of MRP1, MRP2, BCRP, or P-gp, as demonstrated by ATP-dependent uptake in MRP3- and MRP4-overexpressing membrane vesicles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

338.27

Formula

C₁₅H₁₄O₉

CAS No.

66695-14-5

Appearance

Solid

SMILES

O=C1C=CC2=CC=C(C=C2O1)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (147.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9562 mL	14.7811 mL	29.5622 mL
5 mM	0.5912 mL	2.9562 mL	5.9124 mL
10 mM	0.2956 mL	1.4781 mL	2.9562 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (272 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Wittgen HG, et al. Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4. Drug Metab Dispos. 2012;40(6):1076-1079.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9562 mL	14.7811 mL	29.5622 mL	73.9055 mL
	5 mM	0.5912 mL	2.9562 mL	5.9124 mL	14.7811 mL
	10 mM	0.2956 mL	1.4781 mL	2.9562 mL	7.3905 mL
	15 mM	0.1971 mL	0.9854 mL	1.9708 mL	4.9270 mL
	20 mM	0.1478 mL	0.7391 mL	1.4781 mL	3.6953 mL
	25 mM	0.1182 mL	0.5912 mL	1.1825 mL	2.9562 mL
	30 mM	0.0985 mL	0.4927 mL	0.9854 mL	2.4635 mL
	40 mM	0.0739 mL	0.3695 mL	0.7391 mL	1.8476 mL
	50 mM	0.0591 mL	0.2956 mL	0.5912 mL	1.4781 mL
	60 mM	0.0493 mL	0.2464 mL	0.4927 mL	1.2318 mL
	80 mM	0.0370 mL	0.1848 mL	0.3695 mL	0.9238 mL
	100 mM	0.0296 mL	0.1478 mL	0.2956 mL	0.7391 mL