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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
importin
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "importin" in MCE Product Catalog:
16
16 Publications Verification
Importazole is a small molecule inhibitor of the nuclear transport receptor importin-β.
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3 Cited Publications
Cat. No.: HY-P1876B
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3 Cited Publications
Cat. No.: HY-P1876
CAS No.: 95088-49-6
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Cat. No.: HY-170316
Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 .
Synonyms: Ro-31-7453
MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family .
Cat. No.: HY-P10600A
Cat. No.: HY-P1876A
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Cat. No.: HY-P10600
CAS No.: 1105053-46-0
Cat. No.: HY-P10598
CAS No.: 1105053-45-9
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Cat. No.: HY-13691R
CAS No.: 125313-92-0
Synonyms: Ro-31-7453 (Standard)
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MKC-1 (Standard) is the analytical standard of MKC-1. This product is intended for research and analytical applications. MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family .
Cat. No.: HY-RS24383
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Kpna2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kpna2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26948
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Kpna4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kpna4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P11662
CAS No.: 521076-75-5
Cat. No.: HY-P70371
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KPNA2; Nuclear Pore-Targeting Complex 58kD Component; Prev. RCH1; importin Subunit Alpha-2; importin Subunit Alpha-1; importin Subunit Alpha; RAG Cohort Protein 1; Karyopherin Alpha 2; SRP1-Alpha; importin-Alpha-P1; SRP1alpha; importin Alpha 1; PTAC58; RA
Cat. No.: HY-P86934
Synonyms: IMB 1 antibody; IMB1 antibody; IMB1_HUMAN antibody; Impnb antibody; importin 90 antibody; importin beta 1 antibody; importin beta 1 subunit antibody; importin subunit beta-1 antibody; importin-90 antibody; IPOB antibody; IMB 1 antibody; IMB1 antibody; IMB1_HUMAN antibody; Impnb antibody; importin 90 antibody; importin beta 1 antibody; importin beta 1 subunit antibody; importin subunit beta-1 antibody; importin-90 antibody; IPOB antibody; Karyopherin beta 1 antibody; Karyopherin beta 1 subunit antibody; Karyopherin subunit beta-1 antibody; KPNB 1 antibody; Kpnb1 antibody; MGC2155 antibody; MGC2156 antibody; MGC2157 antibody; NTF 97 antibody; NTF97 antibody; NTF97/importin beta antibody; Nuclear factor P97 antibody; Pore targeting complex 97 kDa subunit antibody; PTAC97 antibody;
Cat. No.: HY-P70837
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KPNB1; Karyopherin (importin) Beta 1; Karyopherin Subunit Beta 1; Karyopherin Subunit Beta-1; NTF97; importin 1; Pore Targeting Complex 97 KDa Subunit; MGC2155; importin Subunit Beta-1; MGC2156; Nuclear Factor P97; MGC2157; Impnb; PTAC97; IPOB; importin B
Cat. No.: HY-101091R
CAS No.: 662163-81-7
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Importazole (Standard) is the analytical standard of Importazole (HY-101091). This product is intended for research and analytical applications. Importazole is a small molecule inhibitor of the nuclear transport receptor importin-β.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
