importin

By Targets:	Akt (2) Apoptosis (4) Biochemical Assay Reagents (1) DNA/RNA Synthesis (3) HIV (1) Microtubule/Tubulin (2) Mitosis (2) mTOR (2) Ras (3) Reference Standards (2) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (9) Infection (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101091

Importazole Maximum Cited Publications 16 Publications Verification	Apoptosis	Cancer
Importazole is a small molecule inhibitor of the nuclear transport receptor *importin-β*.

HY-170316

Ibetazol	Ras	Cancer
Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 .

HY-P1876B

NLS (PKKKRKV) hydrochloride 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) hydrochloride is the hydrochloride form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-P1876

NLS (PKKKRKV) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research .

HY-13691

MKC-1 Ro-31-7453	Apoptosis Akt mTOR Microtubule/Tubulin Mitosis	Cancer
MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family .

HY-P10600A

BIMAX2 acetate	Ras	Others
BIMAX2 acetate is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 acetate can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 acetate can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .

HY-P1876A

NLS (PKKKRKV) TFA	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) TFA is the TFA form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-P10600

BIMAX2	Ras	Others
BIMAX2 is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .

HY-P10598

BIMAX1	Biochemical Assay Reagents	Others
BIMAX1 is a tool peptide used in experiments to examine the interaction of RBBP4 with importin β1 and the effects on the nuclear import pathway. BIMAX1 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cellular senescence .

HY-13691R

MKC-1 (Standard) Ro-31-7453 (Standard)	Apoptosis Akt mTOR Microtubule/Tubulin Mitosis Reference Standards	Cancer
MKC-1 (Standard) is the analytical standard of MKC-1. This product is intended for research and analytical applications. MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family .

HY-RS24383

Kpna2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kpna2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kpna2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kpna2 Rat Pre-designed siRNA Set A Kpna2 Rat Pre-designed siRNA Set A

HY-RS26948

Kpna4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kpna4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kpna4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kpna4 Rat Pre-designed siRNA Set A Kpna4 Rat Pre-designed siRNA Set A

HY-101091R

Importazole (Standard)	Apoptosis Reference Standards	Cancer
Importazole (Standard) is the analytical standard of Importazole (HY-101091). This product is intended for research and analytical applications. Importazole is a small molecule inhibitor of the nuclear transport receptor importin-β.

HY-182566

ITI-367	HIV	Infection
ITI-367 is a HIV-1 inhibitor that targets the nuclear localization signal 1 (NLS-1) of HIV-1 matrix protein and the interaction between HIV-1 pre-integration complex (PIC) and *importin-β. ITI-367 inhibits HIV-1* replication at the pre-integration stage, reduces the formation of 2-LTR circles, and sequesters viral DNA in the cytoplasm. ITI-367 can be used for the research of HIV infection .

Cat. No.	Product Name	Target	Research Area

HY-P1876B

NLS (PKKKRKV) hydrochloride 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) hydrochloride is the hydrochloride form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-P1876

NLS (PKKKRKV) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research .

HY-P10600A

BIMAX2 acetate	Ras	Others
BIMAX2 acetate is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 acetate can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 acetate can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .

HY-P1876A

NLS (PKKKRKV) TFA	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) TFA is the TFA form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-P10600

BIMAX2	Ras	Others
BIMAX2 is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .

HY-P10598

BIMAX1	Biochemical Assay Reagents	Others
BIMAX1 is a tool peptide used in experiments to examine the interaction of RBBP4 with importin β1 and the effects on the nuclear import pathway. BIMAX1 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cellular senescence .

HY-P11662

NLS peptide	Peptides	Cancer
NLS peptide is a nuclear localization signal peptide, a short amino acid sequence that can be recognized by nuclear transport machinery (such as the Importin protein complex). NLS peptide can directionally transport the molecules or nanoparticles linked to it into the nucleus, and the N-terminal Cys terminus can be used for subsequent coupling. NLS peptide can be used to construct nucleus-specific imaging probes and nucleus-targeted nanoparticles

HY-P10598A

BIMAX1 acetate	Peptides	Others
BIMAX1 acetate is a tool peptide used in experiments to examine the interaction of RBBP4 with importin β1 and the effects on the nuclear import pathway. BIMAX1 acetate can be used to study the role of RBBP4 in regulating nuclear import efficiency and cellular senescence .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70837

	KPNB1 Protein, Human (His) importin subunit beta-1; importin-90; Karyopherin subunit beta-1; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97; KPNB1; NTF97	Human	E. coli
	KPNB1 is a key player in nuclear protein import, cooperating with adapter proteins such as importin-alpha to recognize nuclear localization signals (NLS) in cargo substrates. In autonomous mode, it acts as its own NLS receptor, facilitating docking of the import/substrate complex to the nuclear pore complex (NPC) via KPNB1. KPNB1 Protein, Human (His) is the recombinant human-derived KPNB1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70371

	Importin alpha-1/KPNA2 Protein, Human (His) rHuimportin subunit alpha-1/KPNA2, His; importin Subunit Alpha-2; Karyopherin Subunit Alpha-2; RAG Cohort Protein 1; SRP1-Alpha; KPNA2; RCH1; SRP1	Human	E. coli
	Importin alpha-1/KPNA2 is essential for nuclear protein import, acting as an adapter for the nuclear receptor KPNB1. It directly binds the substrate to the nuclear localization signal to form a complex that docks with the nuclear pore complex mediated by KPNB1. Importin alpha-1/KPNA2 Protein, Human (His) is the recombinant human-derived Importin alpha-1/KPNA2 protein, expressed by E. coli , with N-6*His labeled tag.

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Tag
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Host:	Mouse (1) Rabbit (8)
Reactivity:	Human (9) Rat (4) Mouse (6)
Application:	IHC-P (4) ICC/IF (7) IF-Tissue (1) IP (4) WB (9) FC (2) ELISA (1)
Isotype:	IgG,Kappa (1) IgG (7)
Conjugation:	Non-conjugated (9)
Clonality:	Monoclonal (8) Recombinant (7)
Modification:	Unmodified (8)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87748

	Importin 9 Antibody (YA7433)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
	Importin 9 Antibody (YA7433) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Importin 9.

HY-P81880

	Importin 9/RANBP9 Antibody (YA1625) importin 9; Imp9; Ran-binding protein 9; RanBP9	WB, ICC/IF, IP	Human
	Importin 9/RANBP9 Antibody (YA1625) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Importin 9/RANBP9.

HY-P81880A

	Importin 9/RANBP9 Antibody (YA1625)(PBS only) importin 9; Imp9; Ran-binding protein 9; RanBP9	WB, ICC/IF, IP	Human
	Importin 9/RANBP9 Antibody (YA1625) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Importin 9/RANBP9.

HY-P86934

	KPNB1 Antibody (YA6627) IMB 1 antibody; IMB1 antibody; IMB1_HUMAN antibody; Impnb antibody; importin 90 antibody; importin beta 1 antibody; importin beta 1 subunit antibody; importin subunit beta-1 antibody; importin-90 antibody; IPOB antibody; IMB 1 antibody; IMB1 antibody; IMB1_HUMAN antibody; Impnb antibody; importin 90 antibody; importin beta 1 antibody; importin beta 1 subunit antibody; importin subunit beta-1 antibody; importin-90 antibody; IPOB antibody; Karyopherin beta 1 antibody; Karyopherin beta 1 subunit antibody; Karyopherin subunit beta-1 antibody; KPNB 1 antibody; Kpnb1 antibody; MGC2155 antibody; MGC2156 antibody; MGC2157 antibody; NTF 97 antibody; NTF97 antibody; NTF97/importin beta antibody; Nuclear factor P97 antibody; Pore targeting complex 97 kDa subunit antibody; PTAC97 antibody;	WB, IHC-P, IF-Tissue, IP	Human, Mouse, Rat
	KPNB1 Antibody (YA6627) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KPNB1.

HY-P82241

	TNPO3 Antibody (YA1986) TNPO 3; Imp12; importin 12; IPO12; MTR10A; TNPO3; Transportin 3; Transportin SR; TRN-SR2; TRNSR	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	TNPO3 Antibody (YA1986) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TNPO3.

HY-P82519

	Cellular Apoptosis Susceptibility Antibody (YA2264) CSE1L; CAS; CSE1; Exp2; importin-alpha re-exporter; Exportin-2; XPO2	WB, IHC-P, ICC/IF, FC	Human, Mouse
	Cellular Apoptosis Susceptibility Antibody (YA2264) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cellular Apoptosis Susceptibility.

HY-P81670

	KPNA2 Antibody (YA1415) KPNA2; RCH1; SRP1; importin subunit alpha-2; Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha	WB, FC	Human, Mouse, Rat
	KPNA2 Antibody (YA1415) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KPNA2.

HY-P82250

	RanBP9 Antibody (YA1995) B cell antigen receptor Ig beta associated protein 1; BPM 90; BPM L; BPM-L; BPM90; BPML; IBAP 1; Imp 9; importin 9; Novel centrosomal protein RanBPM; RAN binding protein 9; Ran binding protein centrosomal; Ran Binding Protein in the Microtubule organizing center; Ran binding protein M; Ran BP9; Ran-binding protein 9; Ran-binding protein M; RANB9_HUMAN; RanBP 7; RANBP 9; RanBP7; RanBP9; RanBPM.	WB, ICC/IF	Human, Mouse, Rat
	RanBP9 Antibody (YA1995) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RanBP9.

HY-P85542

	RanBP9 Antibody (YA5234) B cell antigen receptor Ig beta associated protein 1; BPM 90; BPM L; BPM-L; BPM90; BPML; IBAP 1; Imp 9; importin 9; Novel centrosomal protein RanBPM; RAN binding protein 9; Ran binding protein centrosomal; Ran Binding Protein in the Microtubule organizing center; Ran binding protein M; Ran BP9; Ran-binding protein 9; Ran-binding protein M; RANB9_HUMAN; RanBP 7; RANBP 9; RanBP7; RanBP9; RanBPM.	WB, ICC/IF, IP	Human
	RanBP9 Antibody (YA5234) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to RanBP9.

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Cat. No.	Product Name		Classification

HY-RS24383

Kpna2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Kpna2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kpna2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS26948

Kpna4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Kpna4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kpna4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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