NLS (PKKKRKV) (hydrochloride)

Name: NLS (PKKKRKV) (hydrochloride)
Brand: MedChemExpress
SKU: HY-P1876B
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1876B Purity: 99.60%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NLS (PKKKRKV) hydrochloride is the hydrochloride form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

NLS (PKKKRKV) (hydrochloride) Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of NLS (PKKKRKV) (hydrochloride):

NLS (PKKKRKV) Get quote
NLS (PKKKRKV) (TFA) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

919.60

Formula

C₄₀H₇₉ClN₁₄O₈

Appearance

Solid

Color

White to off-white

Sequence

Pro-Lys-Lys-Lys-Arg-Lys-Val

Sequence Shortening

PKKKRKV

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 500 mg/mL (543.71 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0874 mL	5.4371 mL	10.8743 mL
5 mM	0.2175 mL	1.0874 mL	2.1749 mL
10 mM	0.1087 mL	0.5437 mL	1.0874 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (108.74 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) RP-HPLC (280 KB) Elemental Analysis Report (110 KB)

Handling Instructions (2659 KB)

References

[1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6. [Content Brief]

[2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound‑targeted microbubble destruction‑mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0874 mL	5.4371 mL	10.8743 mL	27.1857 mL
	5 mM	0.2175 mL	1.0874 mL	2.1749 mL	5.4371 mL
	10 mM	0.1087 mL	0.5437 mL	1.0874 mL	2.7186 mL
	15 mM	0.0725 mL	0.3625 mL	0.7250 mL	1.8124 mL
	20 mM	0.0544 mL	0.2719 mL	0.5437 mL	1.3593 mL
	25 mM	0.0435 mL	0.2175 mL	0.4350 mL	1.0874 mL
	30 mM	0.0362 mL	0.1812 mL	0.3625 mL	0.9062 mL
	40 mM	0.0272 mL	0.1359 mL	0.2719 mL	0.6796 mL
	50 mM	0.0217 mL	0.1087 mL	0.2175 mL	0.5437 mL
	60 mM	0.0181 mL	0.0906 mL	0.1812 mL	0.4531 mL
	80 mM	0.0136 mL	0.0680 mL	0.1359 mL	0.3398 mL
	100 mM	0.0109 mL	0.0544 mL	0.1087 mL	0.2719 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLS (PKKKRKV) (hydrochloride)OthersNLSvirusantigenkaryophilic proteinimportin αgene transferInhibitorinhibitorinhibit

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NLS (PKKKRKV) (hydrochloride)

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Other Forms of NLS (PKKKRKV) (hydrochloride):