2. PI3K/Akt/mTOR Cytoskeleton Cell Cycle/DNA Damage Apoptosis
  3. Akt mTOR Microtubule/Tubulin Apoptosis
  4. MKC-1

MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.

For research use only. We do not sell to patients.

MKC-1 Chemical Structure

MKC-1 Chemical Structure

CAS No. : 125313-92-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 286 In-stock
Solution
10 mM * 1 mL in DMSO USD 286 In-stock
Solid
5 mg USD 260 In-stock
10 mg USD 380 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

MKC-1 Related Antibodies

Top Publications Citing Use of Products

View All Akt Isoform Specific Products:

View All Isoforms
Akt Akt1 Akt2 Akt3

View All mTOR Isoform Specific Products:

View All Isoforms
mTOR mTORC1 mTORC2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family[1][2][3].

In Vivo

MKC-1 (200 mg/kg, orally, daily) significantly increased the median survival time (MST) of mice bearing Caki-1 renal cell xenograft tumors[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

400.39

Formula

C22H16N4O4
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC([N+]([O-])=O)=C5)NC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (124.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4976 mL 12.4878 mL 24.9756 mL
5 mM 0.4995 mL 2.4976 mL 4.9951 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4976 mL 12.4878 mL 24.9756 mL 62.4391 mL
5 mM 0.4995 mL 2.4976 mL 4.9951 mL 12.4878 mL
10 mM 0.2498 mL 1.2488 mL 2.4976 mL 6.2439 mL
15 mM 0.1665 mL 0.8325 mL 1.6650 mL 4.1626 mL
20 mM 0.1249 mL 0.6244 mL 1.2488 mL 3.1220 mL
25 mM 0.0999 mL 0.4995 mL 0.9990 mL 2.4976 mL
30 mM 0.0833 mL 0.4163 mL 0.8325 mL 2.0813 mL
40 mM 0.0624 mL 0.3122 mL 0.6244 mL 1.5610 mL
50 mM 0.0500 mL 0.2498 mL 0.4995 mL 1.2488 mL
60 mM 0.0416 mL 0.2081 mL 0.4163 mL 1.0407 mL
80 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7805 mL
100 mM 0.0250 mL 0.1249 mL 0.2498 mL 0.6244 mL
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MKC-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MKC-1125313-92-0Ro-31-7453MKC1MKC 1AktmTORMicrotubule/TubulinApoptosisPKBProtein kinase BMammalian target of RapamycinCaki-1orally activerenal cell cancerpancreatic cancerInhibitorinhibitorinhibit

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