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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
mitochondrion
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "mitochondrion" in MCE Product Catalog:
21
21 Cited Publications
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SKQ1 is a mitochondrial-targeted antioxidant with the high mitochondrion membrane penetrating ability and potent antioxidant capability .
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1 Cited Publications
Cat. No.: HY-P80679
Synonyms: AIFM2; AMID; PRG3; Apoptosis-inducing factor 2; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death; p53-responsive gene 3 protein
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Cat. No.: HY-P3101
CAS No.: 1225021-13-5
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Cat. No.: HY-155062
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IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis .
Cat. No.: HY-146080
CAS No.: 2408917-12-2
Antitumor agent-61 (Compound 9b), Irinotecan (Ir) derivative, is a potential antitumor agent. Antitumor agent-61 displays potent activity with IC50s of 0.92, 1.39, 1.75, 2.20, 3.05 and 3.23 μM against five human cancer cells SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549 and MG-63, respectively. Antitumor agent-61 induces SK-OV-3 cells apoptosis through mitochondrion pathways .
Cat. No.: HY-149918
CAS No.: 3049213-47-7
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Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity .
Cat. No.: HY-106492
CAS No.: 36590-19-9
Synonyms: CGP 6140
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Amocarzine (CGP 6140) is an orally active antifilarial agent. Amocarzine can result in the swelling of mitochondrion and inhibit respiration and other associated metabolic functions. Amocarzine can be used for the research of infection .
Cat. No.: HY-157222
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Antitumor agent-125 (compound 17A) is a novel platinum(IV) prodrug. Antitumor agent-125 can activate the mitochondrion-dependent apoptosis pathway. Antitumor agent-125 induces ferroptosis in HCT-116/OXA .
Cat. No.: HY-P3101A
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Cat. No.: HY-186242
CAS No.: 3123944-18-0
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Magnolol-C4-TPP bromide is a mitochondria-targeted magnolol derivative with cytotoxic activity against cancer cells. Magnolol-C4-TPP bromide increases ROS levels and slightly reduces mitochondrial membrane potential in colon cancer cells. Magnolol-C4-TPP bromide can be used in the research of colorectal cancer, liver cancer, and breast cancer .
Cat. No.: HY-D3269
CAS No.: 2088127-60-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
