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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
myofibroblast activation
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "myofibroblast activation" in MCE Product Catalog:
12
12
12 Publications Verification
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1
1 Cited Publications
1
Category:
Infection Natural Products Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields
Target:
Art. -Nr.: HY-P3136
CAS. Nr.: 25849-90-5
Synonyms: TRV120055
Target:
Forschungsgebiete:
Art. -Nr.: HY-P3136A
Synonyms: TRV120055 hydrochloride
Target:
Forschungsgebiete:
Art. -Nr.: HY-116084S1
CAS. Nr.: 2413127-00-9
Art. -Nr.: HY-107614G
CAS. Nr.: 325465-93-8
Synonyms: 1-Oleoyl-sn-glycero-3-phosphate sodium (GMP); 1-Oleoyl-LPA sodium (GMP)
Art. -Nr.: HY-116084R
CAS. Nr.: 1184-78-7
Art. -Nr.: HY-117485
CAS. Nr.: 1776931-05-5
Target:
Forschungsgebiete:
CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis .
Art. -Nr.: HY-P4890
CAS. Nr.: 1158181-62-4
Target:
RXFP Receptor Reactive Oxygen Species (ROS) Pyroptosis Caspase Interleukin Related TGF-beta/Smad AMPK Apoptosis
Forschungsgebiete:
Target:
Art. -Nr.: HY-W722562
Art. -Nr.: HY-108915R
CAS. Nr.: 62637-93-8
Category:
Art. -Nr.: HY-13692
CAS. Nr.: 187935-17-7
Synonyms: CARD-024
Target:
Forschungsgebiete:
1α-Hydroxyvitamin D5 (CARD-024) is a vitamin D analog with extremely low hypercalcemic effects. 1α-Hydroxyvitamin D5 effectively attenuates the pro-fibrotic response of colonic myofibroblasts to TGFβ and high-stiffness substrates by inhibiting the expression of αSMA, the phosphorylation of FAK, and the gene expression of MLCK and ET-1, while activating the anti-inflammatory pathway of IL-1β/COX-2. 1α-Hydroxyvitamin D5 can be used in research related to intestinal fibrosis associated with Crohn's disease .
Art. -Nr.: HY-P4890A
Target:
RXFP Receptor Reactive Oxygen Species (ROS) Pyroptosis Caspase Interleukin Related TGF-beta/Smad AMPK Apoptosis
Forschungsgebiete:
Art. -Nr.: HY-N0353R
CAS. Nr.: 13657-68-6
Synonyms: (+)-Curdione (Standard)
Art. -Nr.: HY-P11648
CAS. Nr.: 292851-89-9
Target:
Forschungsgebiete:
Art. -Nr.: HY-182274
CAS. Nr.: 3106606-60-1
Target:
Forschungsgebiete:
DM245 is an EPAC1 activator and STAT3 phosphorylation inhibitor with a target pIC50 of 4.801. DM245 activates EPAC1 to increase Rap1-GTP levels, with no activation of EPAC2 or PKA. DM245 reduces IL-6/IL-6Rα-evoked STAT3 phosphorylation in endothelial cells. DM245 suppresses TGF-β1-induced fibroblast-to-myofibroblast transition, reducing αSMA and Collagen I levels. DM245 exhibits minimal cytotoxicity in normal human lung fibroblasts, with negligible loss of intact nuclei after 72 h exposure .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
