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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
nuclear receptor modulator
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "nuclear receptor modulator" in MCE Product Catalog:
6
6 Cited Publications
Synonyms: RAD140; EP0062
Target:
Research Areas:
Vosilasarm (RAD140) is a potent, orally active, nonsteroidal selective androgen receptor modulator (SARM) with a Ki of 7 nM. Vosilasarm shows good selectivity over other steroid hormone nuclear receptors .
3
3 Cited Publications
Synonyms: Abequolixron
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Research Areas:
RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
Cat. No.: HY-P1732
CAS No.: 203716-10-3
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Target:
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TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity .
Cat. No.: HY-N3741
CAS No.: 18296-45-2
Synonyms: Didrovaltratum
Cat. No.: HY-U00429
CAS No.: 1015231-98-7
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NOT Receptor Modulator 1 is a nuclear receptor Nurr-1/NOT modulator extracted from patent WO 2008034974 A1, Example 39 in table1.
Cat. No.: HY-W649594
CAS No.: 22978-55-8
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NR2F6 modulator-2 (Compound I) is an autorepressed orphan nuclear receptor NR2F6 (Nuclear Receptor subfamily 2 group F member 6) modulator. NR2F6 modulator-2 can inhibits the recruitment of the bio-NSD1 peptide with an IC50 of 2.0 equivalents of NR2F6. NR2F6 modulator-2 can be used for the researches of cancer and immunology .
Cat. No.: HY-103578
CAS No.: 404920-28-1
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S-40503 is a tissue-selective androgen receptor (AR) agonist with a Ki of 14.9 nM for rat AR. S-40503 binds to AR with high specificity, exerts full agonistic effects in bone and muscle, acts as a partial agonist in the prostate, and preferentially targets anabolic tissues rather than androgen-dependent tissues. S-40503 can be used in the research of osteoporosis .
Cat. No.: HY-164506
CAS No.: 2375659-15-5
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NRMA-8 is a brain-penetrant small molecule nuclear receptor modulator. NRMA-8 is promising for research of central nervous system disorders, including Alzheimer's disease, Parkinson's disease, demylenation disorders and glioblastomas .
Cat. No.: HY-118912
CAS No.: 457937-39-2
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BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2) . BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models .
Cat. No.: HY-164508
CAS No.: 2375659-13-3
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NRMA-6, an amide prodrug, is a nuclear receptor modulator .
Cat. No.: HY-15731S
Purity: 97.50%
Cat. No.: HY-15731S1
CAS No.: 2734920-42-2
Cat. No.: HY-164504
CAS No.: 2375659-17-7
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NRMA-10, an amide prodrug, is a brain-penetrant nuclear receptor modulator. NRMA-10 increases brain expression of Adam10. NRMA-10 preferres distribution to the CNS compared to the periphery. NRMA-10 can be used for the study of central nervous system (CNS) disorders .
Cat. No.: HY-164512
CAS No.: 1417653-47-4
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NRMA-I is the amide produrg of the small molecule nuclear receptor modulator. NRMA-I exhibits a higher exposure in the brain, indicating that a good blood-brain barrier (BBB) penetration. NRMA-I can be used for research of central nervous system diseases related to nuclear receptors, such as Alzheimer's disease and Parkinson's disease .
Cat. No.: HY-164507
CAS No.: 2375659-14-4
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NRMA-7 is a BBB-penetrable small molecule nuclear receptor modulator. NRMA-7 can be used in the study of central nervous system diseases .
Cat. No.: HY-164505
CAS No.: 2375659-16-6
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NRMA-9 is the amide produrg of the small molecule nuclear receptor modulator. NRMA-9 exhibits a higher exposure in the brain, indicating that a good blood-brain barrier (BBB) penetration. NRMA-9 can be used for research of central nervous system diseases related to nuclear receptors, such as Alzheimer's disease and Parkinson's disease .
Cat. No.: HY-111498AR
CAS No.: 610318-54-2
Synonyms: Abequolixron (Standard)
Target:
Research Areas:
RGX-104 (Standard) is the analytical standard of RGX-104 (HY-111498A). This product is intended for research and analytical applications. RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
Cat. No.: HY-183309
Research Areas:
FXR/HSD17B13-modulator-2 is a dual FXR activator and HSD17B13 inhibitor with human FXR EC50 of 128 nM, human HSD17B13 IC50 of 0.18 μM, high selectivity over related nuclear receptors and HSD17B isoforms, and oral effectiveness.FXR/HSD17B13-modulator-2 alleviates fatty liver, regulates lipid metabolism, reduces inflammation, and attenuates hepatic fibrosis.FXR/HSD17B13-modulator-2 is the first non-carboxylic acid dual FXR/HSD17B13 modulator.FXR/HSD17B13-modulator-2 can be used for the research of metabolic dysfunction-associated steatohepatitis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
