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TLX agonist 1 

Cat. No.: HY-135572 Purity: 99.82%
Handling Instructions

TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity.

For research use only. We do not sell to patients.

TLX agonist 1 Chemical Structure

TLX agonist 1 Chemical Structure

CAS No. : 958323-31-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 807 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

TLX agonist 1 (ccrp2) is an orphan nuclear receptor tailless (TLX, NR2E1) modulator (EC50=1μM; Kd= 650 nM). TLX agonist 1 potentiates TLX transcriptional repressive activity[1].

Molecular Weight

374.48

Formula

C₂₃H₂₆N₄O

CAS No.

958323-31-4

SMILES

O=C(C1=NN(C)C(C)=C1)N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (166.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6704 mL 13.3518 mL 26.7037 mL
5 mM 0.5341 mL 2.6704 mL 5.3407 mL
10 mM 0.2670 mL 1.3352 mL 2.6704 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.55 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.55 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.55 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TLX agonist 1TLX agonist1TLX agonist-1OthersligandorphantranscriptionalrepressiveInhibitorinhibitorinhibit

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Product Name:
TLX agonist 1
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HY-135572
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