NR2F6 modulator-2

Cat. No.: HY-W649594 Purity: 99.46%: Data Sheet
COA

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Handling Instructions
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NR2F6 modulator-2 (Compound I) is an autorepressed orphan nuclear receptor NR2F6 (Nuclear Receptor subfamily 2 group F member 6) modulator. NR2F6 modulator-2 can inhibits the recruitment of the bio-NSD1 peptide with an IC₅₀ of 2.0 equivalents of NR2F6. NR2F6 modulator-2 can be used for the researches of cancer and immunology.

For research use only. We do not sell to patients.

NR2F6 modulator-2 Chemical Structure

CAS No. : 22978-55-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

NR2F6

Molecular Weight

292.67

Formula

C₁₃H₉ClN₂O₄

CAS No.

22978-55-8

Appearance

Solid

Color

Off-white to light brown

SMILES

OC1=CC=C(NC(=O)C2=CC(=CC=C2Cl)[N+]([O-])=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (85.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4168 mL	17.0841 mL	34.1682 mL
5 mM	0.6834 mL	3.4168 mL	6.8336 mL
10 mM	0.3417 mL	1.7084 mL	3.4168 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Purity & Documentation

Purity: 99.46%

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Data Sheet (270 KB) SDS (393 KB)

COA (246 KB) HNMR (258 KB) RP-HPLC (258 KB)

Handling Instructions (2659 KB)

References

[1]. Oerlemans GJM, et al. Structural Elucidation and Covalent Modulation of the Autorepressed Orphan Nuclear Receptor NR2F6. ACS Chem Biol. 2025 Sep 19;20(9):2308-2317. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4168 mL	17.0841 mL	34.1682 mL	85.4204 mL
	5 mM	0.6834 mL	3.4168 mL	6.8336 mL	17.0841 mL
	10 mM	0.3417 mL	1.7084 mL	3.4168 mL	8.5420 mL
	15 mM	0.2278 mL	1.1389 mL	2.2779 mL	5.6947 mL
	20 mM	0.1708 mL	0.8542 mL	1.7084 mL	4.2710 mL
	25 mM	0.1367 mL	0.6834 mL	1.3667 mL	3.4168 mL
	30 mM	0.1139 mL	0.5695 mL	1.1389 mL	2.8473 mL
	40 mM	0.0854 mL	0.4271 mL	0.8542 mL	2.1355 mL
	50 mM	0.0683 mL	0.3417 mL	0.6834 mL	1.7084 mL
	60 mM	0.0569 mL	0.2847 mL	0.5695 mL	1.4237 mL
	80 mM	0.0427 mL	0.2136 mL	0.4271 mL	1.0678 mL