Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
p-p interactions
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "p-p interactions" in MCE Product Catalog:
2
2 Cited Publications
Research Areas:
NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor .
1
1 Cited Publications
Target:
Research Areas:
K67 is a selective the interaction between Keap1 and S349 phosphorylated p62 inhibitor, with an IC50 of 1.5 μM. K67 has a weaker inhibitory effect on the interaction between Keap1 and Nrf2 (IC50 is 6.2 μM). K67 competitively binds to the binding site of Keap1 with p-p62, blocking the abnormal activation of the p62-dependent Nrf2 pathway. K67 inhibits tumor cell proliferation and enhances the sensitivity of hepatocellular carcinoma (HCC) to chemotherapeutic drugs by restoring Keap1-mediated ubiquitination and degradation of Nrf2 .
Cat. No.: HY-D1474
CAS No.: 33628-03-4
WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin . WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region .
Cat. No.: HY-171440
CAS No.: 2570821-88-2
Target:
Research Areas:
Antabactin is an ABA receptor antagonist. Antabactin blocks the ABA receptor-PP2C interaction thereby reducing ABA signaling. Antabactin restores germination of thermoinhibited lettuce .
Cat. No.: HY-170411
CAS No.: 29133-39-9
WNT7A-IN-1 (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 (compound F) is also a photographic sensitizer in the green spectral region .
Cat. No.: HY-124348
CAS No.: 701947-53-7
Synonyms: 3,5-Dimethyl PIT-1
DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer .
Cat. No.: HY-B1812S
CAS No.: 126840-15-1
Synonyms: 1,2-Dimethoxybenzene-d4
Cat. No.: HY-B1812S1
CAS No.: 203645-56-1
Synonyms: 1,2-Dimethoxybenzene-d2
Cat. No.: HY-B1812S3
CAS No.: 24658-24-0
Synonyms: 1,2-Dimethoxybenzene-d6
Cat. No.: HY-W064918
CAS No.: 1473450-60-0
NITD-304 is an orally active anti-tuberculosis agent. NITD-304 exerts inhibitory and bactericidal activities gainst Mycobacterium tuberculosis and multidrug-resistant Mycobacterium tuberculosis. NITD-304 inhibits mycobacterial cell wall biosynthesis and demonstrates synergistic or additive growth inhibitory activity with select antibacterial agents. NITD-304 shows low risk of cardiotoxicity and drug-drug interactions, with no inhibition of major cytochrome P-450 enzymes or hERG channel. NITD-304 can be used for the research of tuberculosis and multidrug-resistant tuberculosis .
Cat. No.: HY-126924
CAS No.: 634600-55-8
(Rac)-Saphenamycin (compound CID_134184) is a gp41 inhibitor with anti-HIV-1 activity. (Rac)-Saphenamycin reveals p-p interactions with Trp571 .
Cat. No.: HY-100858
CAS No.: 433238-84-7
Target:
Research Areas:
PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50=1.4 μM), A(H7N9) and A(H9N2) subtypes .
Cat. No.: HY-B1812S2
CAS No.: 362049-43-2
Synonyms: 1,2-Dimethoxybenzene-d10
Target:
Cat. No.: HY-B1812S4
CAS No.: 3047059-94-6
Synonyms: 1,2-Dimethoxybenzene-d2-1
Cat. No.: HY-136818
CAS No.: 95833-19-5
Target:
Research Areas:
DA 4643 (hydrochloride) is an H2 receptor antagonist with the chemical name 2-guanidino-4 (3-methylaminomethyleneiminophenyl) thiazole dihydrochloride. It has a weak interaction with cytochrome P-450 and has a less inhibitory effect on P-450 than cimetidine and tiotidine. DA 4643 (hydrochloride) is able to inhibit both enzymatic and non-enzymatic lipid peroxidation reactions. This inhibition may not be achieved by inhibiting agent metabolizing enzymes, but rather due to the antioxidant properties of the compound itself. Compared with other H2 receptor antagonists such as cimetidine, ranitidine and tiotidine, DA 4643 (hydrochloride) shows a unique effect in lipid peroxidation inhibition. These properties make DA 4643 (hydrochloride) a potential H2 receptor antagonist with multiple mechanisms of action.
Cat. No.: HY-162927
CAS No.: 1054506-59-0
p53-MDM2-IN-6 (Compound 10a), a LSM-83177 hydrazone analog, is a potent p53-MDM2 inhibitor with an IC50 value of 11.08 µg/mL. p53-MDM2-IN-6 arrests the cell cycle in the S phase and induces early and late Apoptosis with antiproliferative activity against HT29 cell lines with an IC50 value of 10.44 µg/mL. p53-MDM2-IN-6 inhibits p53-MDM2 interaction with increment in p-53 level and decrease the expression of GST enzymes. p53-MDM2-IN-6 is promising for research of colorectal cancer .
Cat. No.: HY-184204
Target:
Research Areas:
Keap1-p-p62-IN-1 is a potent and selective Keap1-p-p62 inhibitor with an IC50 of 0.11 μM. Keap1-p-p62-IN-1 shows 18.73-fold selectivity over Keap1-Nrf2 interaction. Keap1-p-p62-IN-1 normalizes Nrf2 ubiquitination, sensitizes cells to Sorafenib (HY-10201)-induced ferroptosis. Keap1-p-p62-IN-1 can be used for the research of p62 aberrant hepatocellular carcinoma .
Cat. No.: HY-121492
CAS No.: 1414586-62-1
Target:
Research Areas:
NSC 45576 is a selective inhibitor of XendoU endoribonuclease and an inhibitor of CREB-CRE interaction, with an IC50 value of 29 μM against Xenopus laevis XendoU. NSC 45576 binds to the active sites of XendoU and PP11, and inhibits CREB-CRE interaction. NSC 45576 can be used in cancer-related research such as breast cancer and gastric cancer .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
