433238-84-7
433238-84-7
Chemical Structure
PP7
- CAS No.: 433238-84-7
- Formula:C18H14Cl2N2O3
- Molecular Weight:377.22
IUPAC Name: (E)-1-(3,4-dichlorophenyl)-4-(4-ethoxybenzylidene)pyrazolidine-3,5-dione
InChIKey: XFGORAOOZWWQKK-NTEUORMPSA-N
SMILES: ClC1=CC=C(N2C(/C(C(N2)=O)=C/C3=CC=C(OCC)C=C3)=O)C=C1Cl
Biological Activity: PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50=1.4 μM), A(H7N9) and A(H9N2) subtypes[1].
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PP7 | PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50=1.4 μM), A(H7N9) and A(H9N2) subtypes. | |||||||||||||||||||||
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References
Keywords
