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piperine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (3) Bacterial (1) Caspase (1) Cytochrome P450 (3) Dihydroorotate Dehydrogenase (1) Drug Derivative (1) Drug Intermediate (1) Drug Isomer (1) Endogenous Metabolite (3) Environmental Pollutants (1) Ferroptosis (1) Isotope-Labeled Compounds (1) Monoamine Oxidase (1) P-glycoprotein (4) Reference Standards (3) Sodium Channel (1)
By Research Areas:	Cancer (10) Infection (2) Inflammation/Immunology (6) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

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Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0144

*Piperine* 15+ Cited Publications Bioperine; 1-Piperoylpiperidine	Environmental Pollutants Endogenous Metabolite Autophagy P-glycoprotein	Inflammation/Immunology Cancer
Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-N4205

Tetrahydropiperine	Cytochrome P450	Cancer
Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs<、b>, and an activator of the PI3K/Akt/mTOR<、b> pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke .

HY-N0144R

Piperine (Standard) Bioperine (Standard); 1-Piperoylpiperidine (Standard)	Reference Standards P-glycoprotein Autophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Piperine (Standard) is the analytical standard of Piperine. This product is intended for research and analytical applications. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-W748509

Pipernonaline	Caspase Apoptosis	Cancer
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-W654320

Piperin-d10 Bioperine-d₁₀; 1-Piperoylpiperidine-d₁₀	Isotope-Labeled Compounds Endogenous Metabolite P-glycoprotein Autophagy	Cancer
Piperin-d₁₀ is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-100377

Lvguidingan Anticonvulsant 7903	Others	Neurological Disease
Lvguidingan is a potent anticonvulsant agent. Lvguidingan also has sedative-hypnotic, tranquilizing, and muscle-relaxing actions. Lvguidingan can be used as antiepileptic agent .

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Cytochrome P450 P-glycoprotein	Neurological Disease Inflammation/Immunology Cancer
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-N4205R

Tetrahydropiperine (Standard)	Reference Standards Cytochrome P450	Cancer
Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .

HY-159119

hDHODH-IN-15	Dihydroorotate Dehydrogenase Ferroptosis	Cancer
hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC₅₀ of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC₅₀ of 0.95-2.81 µM. hDHODH-IN-15 induces ferroptosis in HCT-116, and exhibits antitumor efficacy .

HY-N12134

Methyl piperate	Monoamine Oxidase	Neurological Disease
Methylpiperic acid is a piperine alkaloid with significant MAO inhibitory activity (IC₅₀3.6 μM). Methylpiperic acid is less effective against MAO-B (IC 501.6 μM) than MAO-A (IC₅₀27.1 μM) has a bidirectional inhibitory effect. Methylphenidate is used to research mental disorders .

HY-178921

HJ-4	Drug Derivative Apoptosis	Cancer
HJ-4 is a Piperine (HY-N0144) derivative. HJ-4 potently inhibits the proliferation of CRC cells by dose-dependently reducing colony formation and DNA synthesis. HJ-4 markedly suppresses the adhesion, migration, invasion and induces apoptosis of CRC cells. HJ-4 demonstrates anti-tumor efficacy in chicken embryo chorioallantoic membrane (CAM) model implanted with HCT116/SW480 tumor spheroids. HJ-4 can be used for the study of colorectal cancer (CRC) .

HY-N18780

Piper longum extract	Bacterial	Infection Inflammation/Immunology
Piper longum extract contains a variety of key active ingredients, including piperine, piperidine, and essential oils, which give it anti-inflammatory, antioxidant, antibacterial, and digestive-promoting effects.

HY-N0144A

Isopiperine	Drug Isomer	Infection
Isopiperine is the geometric isomer of Piperine (HY-N0144). Isopiperine can be isolated from pepper. Isopiperine shows antifeedant activity against S. litura with an ED₅₀ of 0.058 (μmol/cm ²) .

HY-N19084

Piper longum fruit extract	Others	Inflammation/Immunology Cancer
Piper longum fruit extract contains a variety of bioactive compounds, including piperine, flavonoids, phenolic compounds, and various alkaloids. Piper longum fruit extract has applications such as antioxidant activity, anti-inflammatory effects, antitumor and immunomodulatory properties, hepatoprotective effects, and anti-chromosome breakage activity.

HY-W100681R

2'-Hydroxy-5'-methylacetophenone (Standard)	Drug Intermediate Reference Standards	Others
Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .

HY-179445

Nav1.7-IN-20	Sodium Channel	Neurological Disease Inflammation/Immunology
Nav1.7-IN-20 (Compound 3AG) is an orally active Nav1.7 channel inhibitor with an IC₅₀ of 3.1 μM. Nav1.7-IN-20 demonstrates analgesic efficacy in a complete Freund's adjuvant (CFA) inflammatory pain model. Nav1.7-IN-20 can be used for pain research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0144

*Piperine* 15+ Cited Publications Bioperine; 1-Piperoylpiperidine	Structural Classification Classification of Application Fields Piperaceae Plants Endogenous metabolite Piper nigrum Linn. Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite Autophagy P-glycoprotein
Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-N4205

Tetrahydropiperine	Alkaloids Piperidine Alkaloids Classification of Application Fields Piperaceae Plants Disease Research Fields Piper nigrum Linn. Source Classification Cancer	Cytochrome P450
Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs<、b>, and an activator of the PI3K/Akt/mTOR<、b> pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke .

HY-N0144R

Piperine (Standard) Bioperine (Standard); 1-Piperoylpiperidine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Piperaceae Plants Endogenous metabolite Piper nigrum Linn. Source Classification	Reference Standards P-glycoprotein Autophagy Endogenous Metabolite
Piperine (Standard) is the analytical standard of Piperine. This product is intended for research and analytical applications. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-W748509

Pipernonaline	Piper longum Linn. Alkaloids Piperidine Alkaloids Piperaceae Plants Source Classification	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Alkaloids Piperidine Alkaloids Piperaceae Plants Piper nigrum Linn. Source Classification	Cytochrome P450 P-glycoprotein
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-N4205R

Tetrahydropiperine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Piperaceae Plants Piper nigrum Linn. Source Classification	Reference Standards Cytochrome P450
Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine. This product is intended for research and analytical applications. Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM) .

HY-N12134

Methyl piperate	Piper longum Linn. Structural Classification Natural Products Piperaceae Plants Source Classification	Monoamine Oxidase
Methylpiperic acid is a piperine alkaloid with significant MAO inhibitory activity (IC₅₀3.6 μM). Methylpiperic acid is less effective against MAO-B (IC 501.6 μM) than MAO-A (IC₅₀27.1 μM) has a bidirectional inhibitory effect. Methylphenidate is used to research mental disorders .

HY-N18780

Piper longum extract	Structural Classification Extract	Bacterial
Piper longum extract contains a variety of key active ingredients, including piperine, piperidine, and essential oils, which give it anti-inflammatory, antioxidant, antibacterial, and digestive-promoting effects.

HY-N0144A

Isopiperine	Structural Classification Alkaloids Piperidine Alkaloids Piperaceae Plants Piper nigrum Linn. Source Classification	Drug Isomer
Isopiperine is the geometric isomer of Piperine (HY-N0144). Isopiperine can be isolated from pepper. Isopiperine shows antifeedant activity against S. litura with an ED₅₀ of 0.058 (μmol/cm ²) .

HY-N19084

Piper longum fruit extract	Structural Classification Extract	Others
Piper longum fruit extract contains a variety of bioactive compounds, including piperine, flavonoids, phenolic compounds, and various alkaloids. Piper longum fruit extract has applications such as antioxidant activity, anti-inflammatory effects, antitumor and immunomodulatory properties, hepatoprotective effects, and anti-chromosome breakage activity.

Cat. No.	Product Name	Chemical Structure

HY-W654320

Piperin-d10
Piperin-d₁₀ is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

Cat. No.	Product Name		Classification

HY-159119

hDHODH-IN-15		Alkynes
hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC₅₀ of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC₅₀ of 0.95-2.81 µM. hDHODH-IN-15 induces ferroptosis in HCT-116, and exhibits antitumor efficacy .

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piperine

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products