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Results for "

rat PDE3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphodiesterase (PDE) (5) Adenylate Cyclase (2) Prostaglandin Receptor (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cardiovascular Disease (3) Endocrinology (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Oligonucleotides

Targets Recommended: Phosphodiesterase (PDE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131545

Parogrelil NT-702 free base; NT-702 free base	Phosphodiesterase (PDE)	Others
Parogrelil (NT-702 free base) is a compound with intermittent claudication inhibitory activity that inhibits PDE3, inhibits platelet aggregation and vasoconstriction, and improves walking distance and plantar surface temperature in a rat experimental model.

HY-116540A

L 858051 dihydrochloride 7DMB-Forskolin	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin) dihydrochloride, an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 dihydrochloride directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 dihydrochloride activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 dihydrochloride maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 dihydrochloride increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 dihydrochloride serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .

HY-111219

Parogrelil hydrochloride NM-702; NT-702	Phosphodiesterase (PDE)	Others
Parogrelil (hydrochloride) (NM-702) is a phosphodiesterase inhibitor with activity in inhibiting intermittent claudication. Parogrelil (hydrochloride) selectively inhibits PDE3, inhibits human platelet aggregation in vitro and rat aortic contraction, and improves walking distance and plantar surface temperature in the rat femoral artery ligation model, with better effects than cilostazol.

HY-116540

L 858051 7DMB-Forskolin free base	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin free base), an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .

HY-120029

Org-9935	Phosphodiesterase (PDE)	Endocrinology
Org-9935 is a selective inhibitor of *PDE3* with an IC₅₀ of 50 nM. Org-9935 inhibits maturation of oocyte in naturally selected dominant follicle in rhesus macaques. Org-9935 can augment glucose-induced insulin release in isolated rat islets with an EC₅₀ of 20 μM .

HY-RS10218

Pde3a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pde3a Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde3a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pde3a Rat Pre-designed siRNA Set A Pde3a Rat Pre-designed siRNA Set A

HY-W700639

Tolafentrine	Phosphodiesterase (PDE)	Neurological Disease
Tolafentrine, a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor, has been shown to have significant acute and chronic effects in a unilateral diacetamide-induced rat pulmonary hypertension model. Experiments show that long-term administration can significantly alleviate all unilateral bisacetamide-induced hemodynamic and gas exchange abnormalities, reduce right ventricular hypertrophy, and normalize pulmonary vascular remodeling changes .

HY-180345

ND-7001	Prostaglandin Receptor	Neurological Disease
ND-7001 is an inhibitor of *PDE2* with an IC₅₀ of 0.05 μM. ND-7001 exhibits good selectivity agianst PDE3 and PDE4. ND-7001 increases cGMP levels in primary neuronal cultures of rat cerebral cortical neurons. ND-7001 displays anxiolytic effects .

HY-RS24880

Pde3b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pde3b Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde3b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pde3b Rat Pre-designed siRNA Set A Pde3b Rat Pre-designed siRNA Set A

HY-113822

Lixazinone hydrogensulfate RS-82856 hydrogensulfate	Phosphodiesterase (PDE)	Cardiovascular Disease Endocrinology
Lixazinone (RS-82856) hydrogensulfate is a selective inhibitor of cGMP-inhibited phosphodiesterase (PDE3) with an IC₅₀ value of 22 nM. Lixazinone hydrogensulfate exhibits positive inotropic effects, afterload reduction and antithrombotic properties. Lixazinone hydrogensulfate increases cyclic adenosine monophosphate (cAMP) levels in human platelets, inhibits thrombin-induced aggregation of human platelets, and blocks the photolabeling of PDE3 active sites by [ ³²P]cGMP. Lixazinone hydrogensulfate can be used in the research of polycystic kidney disease and congestive heart failure .

Pde3a Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pde3a Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde3a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pde3b Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pde3b Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde3b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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