129425-83-8
129425-83-8
Chemical Structure
Org-9935
- CAS No.: 129425-83-8
- Formula:C15H16N2O3S
- Molecular Weight:304.36
IUPAC Name: 6-(5,6-dimethoxybenzo[b]thiophen-2-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
InChIKey: KIYDKXDCNSPKQQ-UHFFFAOYSA-N
SMILES: O=C1CC(C)C(C2=CC3=CC(OC)=C(OC)C=C3S2)=NN1
Biological Activity: Org-9935 is a selective inhibitor of PDE3 with an IC50 of 50 nM. Org-9935 inhibits maturation of oocyte in naturally selected dominant follicle in rhesus macaques. Org-9935 can augment glucose-induced insulin release in isolated rat islets with an EC50 of 20 μM[1][2][3].
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Org-9935 | Org-9935 is a selective inhibitor of PDE3 with an IC50 of 50 nM. Org-9935 inhibits maturation of oocyte in naturally selected dominant follicle in rhesus macaques. Org-9935 can augment glucose-induced insulin release in isolated rat islets with an EC50 of 20 μM. | |||||||||||||||||||||
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References
- [1]. Dent, G., et al., (1991). Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors. British journal of pharmacology, 103(2), 1339-1346. [Content Brief]
- [2]. El-Metwally, M., et al., (1997). The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. European journal of pharmacology, 324(2-3), 227-232. [Content Brief]
- [3]. Jensen, J. T., et al., (2008). The phosphodiesterase 3 inhibitor ORG 9935 inhibits oocyte maturation in the naturally selected dominant follicle in rhesus macaques. Contraception, 77(4), 303-307. [Content Brief]
Keywords
