Search Result

Results for "

somnifera

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (2) Cholinesterase (ChE) (1) Drug Derivative (1) Drug Metabolite (1) ERK (2) Ferroptosis (2) GABA Receptor (1) HSP (1) iGluR (2) NF-κB (2) Reference Standards (5) RET (1) RUNX (2) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (10) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (8)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2065

Withaferin A 10+ Cited Publications	NF-κB Ferroptosis	Inflammation/Immunology Cancer
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N10889

Sominone	Drug Metabolite RET	Neurological Disease
Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-129566

Withanolide B	ERK Wnt β-catenin RUNX	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B is an active component of W. somnifera* Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2* and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-129692

Withanone 1 Publications Verification	iGluR	Neurological Disease Cancer
Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

HY-N2065R

Withaferin A (Standard)	Reference Standards NF-κB Ferroptosis	Inflammation/Immunology Cancer
Withaferin A (Standard) is the analytical standard of Withaferin A. This product is intended for research and analytical applications. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N7195

12-Deoxywithastramonolide	Others	Others
12-Deoxywithastramonolide is a principle bioactive compound found in ashwagandha (W. somnifera). 12-Deoxywithastramonolide possesses antioxidant and enzyme inhibitory effects .

HY-N5069

2,3-Didehydrosomnifericin	Bacterial	Others
2,3-Didehydrosomnifericin is one of withanolides found in Withania somnifera .

HY-N5120

Dihydrowithaferin A 2,3-Dihydrowithaferin A	Cholinesterase (ChE)	Cancer
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE) .

HY-N5131

3β-Methoxy-2,3-dihydrowithaferin A Quresimin A	Others	Others
3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera .

HY-N5113

6α-Chloro-5β-hydroxywithaferin A	Bacterial	Others
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .

HY-N10884

Withasomniferolide A	Others	Others
Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

HY-N10887

Withasomniferolide B	GABA Receptor	Neurological Disease
Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

HY-138146

4-Dehydrowithaferin A 4-oxo Withaferin A	Drug Derivative	Cancer
4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .

HY-N11702

Kaempferol-3-O-robinoside-7-O-glucoside	Others	Others
Kaempferol-3-O-robinoside-7-Oglucoside is a double-chain flavonol triglycoside can be extracted from Withania somnifera .

HY-N7195R

12-Deoxywithastramonolide (Standard)	Reference Standards Others	Others
12-Deoxywithastramonolide (Standard) is the analytical standard of 12-Deoxywithastramonolide. This product is intended for research and analytical applications. 12-Deoxywithastramonolide is a principle bioactive compound found in ashwagandha (W. somnifera). 12-Deoxywithastramonolide possesses antioxidant and enzyme inhibitory effects .

HY-N18728

*Withania somnifera* extract**	Others	Neurological Disease
Withania somnifera extract, derived from the roots and leaves of the South African ashwagandha (Withania somnifera), contains a variety of bioactive components, including solanolactones (such as solanolactone A, solanolactone D, and solanine A), solanosin (such as solanosin IV and solanosin VI), alkaloids (such as isopretiline and anaflin), β-sitosterol, benzoic acid, and tropane alkaloids. Withania somnifera extract has been extensively studied for its benefits in stress management, anxiety relief, improved physical function, and overall health.

HY-N8671R

Withanoside V (Standard)	Reference Standards Others	Neurological Disease
Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

HY-129566R

Withanolide B (Standard)	Reference Standards ERK Wnt β-catenin RUNX	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-129692R

Withanone (Standard)	Reference Standards iGluR	Neurological Disease Cancer
Withanone (Standard) is the analytical standard of Withanone (HY-129692). This product is intended for research and analytical applications. Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

HY-N10949

Viscosalactone B	Others	Cancer
Viscosalactone B is a withanolide found in Withania somnifera. Viscosalactone B shows potent inhibitory activities to NCI-H460, HCT-116, MCF-7 and SF-268 cancer cells with IC₅₀ values of 0.32, 0.47, 0.4 and 0.45 μg/mL. Viscosalactone B can be used for the research of cancer .

HY-N17756

Withanolide D	HSP	Cancer
Withanolide D (Compound 2) is a steroidal ester found in Withania somnifera (L.) Dunal, with anticancer activity. Withanolide D can activate the heat-shock factor 1 (HSF1)-dependent stress response. Withanolide D can be used for the research of cancer such as lymphoma .

Withaferin A 10+ Cited Publications	Structural Classification other families Classification of Application Fields Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	NF-κB Ferroptosis
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

Sominone	Withania somnifera Solanaceae Plants Steroids Source Classification	Drug Metabolite RET
Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

Withanolide B	Neurological Disease Classification of Application Fields Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	ERK Wnt β-catenin RUNX
Withanolide B is an active component of W. somnifera* Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2* and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

Withanone 1 Publications Verification	Withania somnifera Solanaceae Plants Steroids Source Classification	iGluR
Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

Withaferin A (Standard)	Structural Classification other families Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards NF-κB Ferroptosis
Withaferin A (Standard) is the analytical standard of Withaferin A. This product is intended for research and analytical applications. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

12-Deoxywithastramonolide	other families Classification of Application Fields Other Diseases Plants Disease Research Fields Steroids Source Classification	Others
12-Deoxywithastramonolide is a principle bioactive compound found in ashwagandha (W. somnifera). 12-Deoxywithastramonolide possesses antioxidant and enzyme inhibitory effects .

2,3-Didehydrosomnifericin	other families Classification of Application Fields Other Diseases Plants Disease Research Fields Steroids Source Classification	Bacterial
2,3-Didehydrosomnifericin is one of withanolides found in Withania somnifera .

Dihydrowithaferin A 2,3-Dihydrowithaferin A	Classification of Application Fields Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer Source Classification	Cholinesterase (ChE)
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE) .

3β-Methoxy-2,3-dihydrowithaferin A Quresimin A	other families Classification of Application Fields Other Diseases Plants Disease Research Fields Steroids Source Classification	Others
3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera .

6α-Chloro-5β-hydroxywithaferin A	Structural Classification Classification of Application Fields Other Diseases Withania somnifera Solanaceae Plants Disease Research Fields Steroids Source Classification	Bacterial
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .

Withasomniferolide A	Withania somnifera Plants Solanaceae Steroids Source Classification	Others
Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

Withasomniferolide B	Withania somnifera Plants Solanaceae Steroids Source Classification	GABA Receptor
Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

4-Dehydrowithaferin A 4-oxo Withaferin A	Quinones Classification of Application Fields Benzene Quinones Withania somnifera Solanaceae Plants Disease Research Fields Source Classification Cancer	Drug Derivative
4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .

Kaempferol-3-O-robinoside-7-O-glucoside	Flavonoids Flavones Withania somnifera Plants Solanaceae Source Classification	Others
Kaempferol-3-O-robinoside-7-Oglucoside is a double-chain flavonol triglycoside can be extracted from Withania somnifera .

12-Deoxywithastramonolide (Standard)	other families Plants Steroids Source Classification	Reference Standards Others
12-Deoxywithastramonolide (Standard) is the analytical standard of 12-Deoxywithastramonolide. This product is intended for research and analytical applications. 12-Deoxywithastramonolide is a principle bioactive compound found in ashwagandha (W. somnifera). 12-Deoxywithastramonolide possesses antioxidant and enzyme inhibitory effects .

*Withania somnifera* extract**	Structural Classification Extract	Others
Withania somnifera extract, derived from the roots and leaves of the South African ashwagandha (Withania somnifera), contains a variety of bioactive components, including solanolactones (such as solanolactone A, solanolactone D, and solanine A), solanosin (such as solanosin IV and solanosin VI), alkaloids (such as isopretiline and anaflin), β-sitosterol, benzoic acid, and tropane alkaloids. Withania somnifera extract has been extensively studied for its benefits in stress management, anxiety relief, improved physical function, and overall health.

Withanoside V (Standard)	Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards Others
Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

Withanolide B (Standard)	Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards ERK Wnt β-catenin RUNX
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

Withanone (Standard)	Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards iGluR
Withanone (Standard) is the analytical standard of Withanone (HY-129692). This product is intended for research and analytical applications. Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

Viscosalactone B	Structural Classification Withania somnifera Solanaceae Plants Steroids Source Classification	Others
Viscosalactone B is a withanolide found in Withania somnifera. Viscosalactone B shows potent inhibitory activities to NCI-H460, HCT-116, MCF-7 and SF-268 cancer cells with IC₅₀ values of 0.32, 0.47, 0.4 and 0.45 μg/mL. Viscosalactone B can be used for the research of cancer .

Withanolide D	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	HSP
Withanolide D (Compound 2) is a steroidal ester found in Withania somnifera (L.) Dunal, with anticancer activity. Withanolide D can activate the heat-shock factor 1 (HSF1)-dependent stress response. Withanolide D can be used for the research of cancer such as lymphoma .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

somnifera

Inhibitors & Agonists

NaturalProducts

Natural
Products