76938-46-0
Chemical Structure
Viscosalactone B
- CAS No.: 76938-46-0
- Formula:C28H40O7
- Molecular Weight:488.61
IUPAC Name: (E)-3-(3-hydroxy-4-methoxyphenyl)-N-(4-hydroxyphenethyl)acrylamide
InChIKey: WVMINIQLCDVTLH-IVFYTCICSA-N
SMILES: C[C@]12[C@@]3([C@H]([C@H](CC2=O)O)O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@@H]([C@@]6([H])CC(C)=C(C(O6)=O)CO)C)C)([H])O3
Biological Activity: Viscosalactone B is an orally active LSD1 inhibitor with an IC50 of 970.27 nM. Viscosalactone B targets COX-2, inhibits cyclooxygenase activity, and inhibits p97 ATPase activity in a cysteine-dependent manner. Viscosalactone B can be used in cancer-related research such as prostate cancer, lung cancer, and breast cancer[1][2][3][4][5][6].
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Viscosalactone B | Viscosalactone B is an orally active LSD1 inhibitor with an IC50 of 970.27 nM. Viscosalactone B targets COX-2, inhibits cyclooxygenase activity, and inhibits p97 ATPase activity in a cysteine-dependent manner. Viscosalactone B can be used in cancer-related research such as prostate cancer, lung cancer, and breast cancer. | |||||||||||||||||||||
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References
- [1]. Khairy A, et al. Discovery of potential natural dihydroorotate dehydrogenase inhibitors and their synergism with brequinar via integrated molecular docking, dynamic simulations and in vitro approach. Scientific reports. 2022 Nov 09;12(1):19037. [Content Brief]
- [2]. Yan G, et al. Viscosalactone B, a natural LSD1 inhibitor, inhibits proliferation in vitro and in vivo against prostate cancer cells. Invest New Drugs. 2023 Feb;41(1):134-141. [Content Brief]
- [3]. Jayaprakasam B, et al. Cyclooxygenase-2 enzyme inhibitory withanolides from Withania somnifera leaves. Tetrahedron. 2003;59(6):841–849.
- [4]. Jayaprakasam B, et al. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. Life sciences. 2003 Nov 21;74(1):125-32. [Content Brief]
- [5]. Santagata S, et al. Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS chemical biology. 2012 Feb 17;7(2):340-9. [Content Brief]
- [6]. Tao S, et al. Withaferin A Analogs That Target the AAA+ Chaperone p97. ACS chemical biology. 2015 Aug 21;10(8):1916-1924. [Content Brief]
