5α-Dihydrocortisol
Based on 1 Customer Validation
5α-Dihydrocortisol (5α-DHF), a metabolite of Hydrocortisone (Cortisol) (HY-N0583), is a steroid hormone. 5α-Dihydrocortisol can enhance the mineralocorticoid activity of aldosterone.
For research use only. We do not sell to patients.
- Purity: 98.17%
- CAS No.: 516-41-6
- Formula: C21H32O5
- Molecular Weight:364.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
In the adrenalectomized rat kidney, in vitro, 5α-Dihydrocortisol (5α-DHF) has 20% the affinity of Dexamethasone (HY-14648) for classical (type II) glucocorticoid receptors, 10% the affinity of Corticosterone (HY-B1618) for (type III) corticosteroid-binding globulin-like glucocorticoid receptors, and 3% the affinity of Aldosterone (HY-113313) for mineralocorticoid receptors (type I). 5α-Dihydrocortisol has <0.1% the affinity of Dihydrotestosterone in mouse kidney receptors and <0.1% the affinity of both Estradiol (HY-B0141) and Progesterone (HY-N0437) for their receptors in rat uterus[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 516-41-6
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Appearance Solid
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Molecular Weight 364.48
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Formula C21H32O5
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Color White to off-white
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SMILES
C[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4([C@@](CC(CC4)=O)([H])CC3)C
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Synonyms
5α-DHF
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Adam WR, et al. Amplification of the action of aldosterone by 5 alpha-dihydrocortisol. Endocrinology. 1978 Aug;103(2):465-71. [Content Brief]
[2]. Mikami H, et al. The effect of 5 alpha-dihydrocortisol on the blood pressure of rats treated with deoxycorticosterone acetate and salt. Endocrinol Jpn. 1980 Dec;27(6):769-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5α-Dihydrocortisol Related Classifications
HY-W741872 Related Classifications
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