2. Protein Tyrosine Kinase/RTK
  3. Src
  4. SRC-3-IN-1

SRC-3-IN-1(compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor(IC50=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research.

For research use only. We do not sell to patients.

SRC-3-IN-1 Chemical Structure

SRC-3-IN-1 Chemical Structure

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SRC-3-IN-1 Related Antibodies

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Description

SRC-3-IN-1(compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor(IC50=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research[1].

In Vitro

SRC-3-IN-1(different concentrations, 72 h) has a high potency against various cancer cell lines[1].
SRC-3-IN-1 exhibits high selectivity away from these off-targets compared to the single digit nanomole potency[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SRC-3-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: Panc-1, HPAC, Mpanc-96, MDA-MB-468, MCF-7, BT-474 and LNCaP cell lines
Concentration:
Incubation Time: 72 h
Result: Exhibited very potent cytotoxicity against these cell lines, with IC50 values ranging from 1 to 32 nM
In Vivo

SRC-3-IN-1(50, 100 mg/kg, po.; everyday for 4 weeks) do not cause any loss of body weight[1].
SRC-3-IN-1(10 mg/kg, ip.; everyday for 4 weeks) prolongs mouse survival compared to the vehicle control group by inhibiting tumor angiogenesis[1].
SRC-3-IN-1(10 mg/kg/day, ip.; 4 weeks) decreases the ratio of tumor area to femur area by over 50%[1].

Pharmacokinetic Analysis in CD-1 Mice[1]

Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0_t (ng•h/mL) Cl (L•h/kg) F (%)
i.v. 1 3.25 0.033 552 87.6 176 /
p.o. 10 9.09 0.25 89 477 / 54.4

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: xenograft prostate cancer mouse model[1]
Dosage: 10 mg/kg
Administration: i.p.
Result: Resulted in a substantial inhibition of tumor growth after only 1 week and exhibited a remarkable reduction in tumor growth by more than 65% compared to the vehicle after 4 weeks.
Molecular Weight

302.28

Formula

C14H12F2N6
Unlabeled CAS

SMILES

C/C(C1=NC=CC=N1)=N\N=C2N(C3=C(N\2)C=C(F)C(F)=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SRC-3-IN-1 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRC-3-IN-1SrcSRC-3 inhibitorPanc-1HPACMpanc-96MDA-MB-468MCF-7BT-474 and LNCaP cell linesprostatic cancerInhibitorinhibitorinhibit

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