1. Epigenetics
  2. Histone Demethylase
  3. T-448

T-448 

Cat. No.: HY-122635A
Handling Instructions

T-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons.

For research use only. We do not sell to patients.

T-448 Chemical Structure

T-448 Chemical Structure

CAS No. : 1597426-53-3

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Description

T-448 is a specific and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1].

IC50 & Target

IC50: 22 nM (LSD1)[1].

Molecular Weight

772.94

Formula

C₃₈H₄₄N₈O₆S₂

CAS No.

1597426-53-3

SMILES

O=C(NC1=NN=C(C)S1)C2=CC=CC([[email protected]]3[[email protected]](NC4CCC4)C3)=C2.O=C(NC5=NN=C(C)S5)C6=CC=CC([[email protected]]7[[email protected]](NC8CCC8)C7)=C6.O=C(O)/C=C/C(O)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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T-448
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